Histological analysis showed lower lipid accumulation in the DM/G-CSF group than in the DM/saline-treated rats. Protein levels of LC3 and beclin-1 were higher, and those of p62 were lower in the DM/G-CSF rats than in the DM/saline-treated rats. The mRNA expression of

-oxidation-related genes was higher in DM/G-CSF rats than in the DM/saline-treated rats. Quantification of lipid levels in HepG2 cells cultured with HG and G-CSF treatment revealed no significant differences.

Our data suggested that G-CSF potentially improves hepatic steatosis and autophagy in the liver of diabetic rats.

Our data suggested that G-CSF potentially improves hepatic steatosis and autophagy in the liver of diabetic rats.Background Cancer patients are usually filled with fear and anxiety but hardiness is a personal characteristic that makes them stronger, resistant, and optimistic in dealing with the pressures related to the disease. There are, however, several factors influencing hardiness and those include social support, parenting, and selfconfidence. Therefore, the objective of this study was to identify these factors in cancer patients at the Indonesian Cancer Foundation in Surabaya. Design and Methods The study made use of observational design with a population of 70 and a total sample of 64 cancer patients were selected as respondents using simple random sampling. The research instrument used for data collection was a questionnaire and results were analyzed using Spearman statistical test. Results The results showed social support was 0.009, parenting patterns was 0.035, and confidence was 0.647. Therefore, H1 was accepted and this means there was a relationship between support and hardiness, as well as parenting patterns and hardiness. Moreover, H0 was also accepted and this indicates self-confidence did not have any influence on hardiness. Conclusions In conclusion, providing adequate support and good parenting have the ability to increase hardiness.

Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases in the older population and characterized by progressive memory and cognitive impairment.

, a traditional medicinal herb, has analgesic, sedative, and anti-inflammatory effects and also used to increase memory in Islamic traditional medicine. This study was designed to consider the effects of

extract on memory impairment and neurogenesis in the Beta-Amyloid rats’ model.

Forty-two male Wistar rats were randomly divided into six groups (

= 7) for the evaluation of baseline training performance in the Morris water maze test. Then, amyloid-beta (Aβ1-42) was injected in animal hippocampal CA1 bilaterally in four groups. The first probe trial was performed 21 days after Aβ injection. Then, 250, 500, and 750 mg/kg of

extract were administered to three Aβ-injected groups for 1 month; after that, the second probe trial was performed, and rats were sacrificed after 28 days of the second probe trial. The neurogenesis was detected in the hippocampus, by immunohistochemical staining.

This study showed that spatial memory increased in the behavioral test in AD treated group with

extract, compared with the AD group (

= 0.02). Immunohistochemical staining revealed that neuronal differentiation has been occurred in the hippocampus in the AD-treated group with

extract compared with the AD group (

= 0.01).

This study showed that

extract, repaired spatial memory impairment in the Aβ rats, through increased neurogenesis in the hippocampus, which could be related to the flavonoid components in the extract.

This study showed that C. rotundus extract, repaired spatial memory impairment in the Aβ rats, through increased neurogenesis in the hippocampus, which could be related to the flavonoid components in the extract.

Anelloviridae is a viral family which is considered as a constant component of human virome. Given the ubiquitous nature of the virus infection and the long-standing relationship between the virus and the host, in the present study, we aimed at investigating the presence of Anelloviruses in the urine samples of children in a cross-sectional study.

The urine samples of 50 children who were referred to Hazrat Ali Asghar Children’s Hospital, affiliated to Iran University of Medical Sciences, Tehran, Iran, were obtained. Three TaqMan real-time polymerase chain reactions (PCRs) were carried out for Anellovirus detection. A phylogenetic tree was drawn for positive products after PCR amplification, purification, and nucleotide sequencing. SPSS, version 20, was used for statistical analyses.

Children’s mean age ± standard deviation was 4.30 ± 1.47 years and 56% (28/50) were female. Real-time PCR revealed that Anellovirus was positive in 12% (6/50). Furthermore, PCR-sequencing results showed that torque teno virus was detected in 83.3% (5/6) and SEN virus in 16.6% (1/6) of the Anellovirus positive samples. In addition, 86% (5/6) of the children with positive samples were female. No significant difference was detected between any of the demographic characteristics and Anellovirus positivity (

> 0.05).

According to our preliminary study, the presence of Anelloviruses in the urine samples of asymptomatic children in Iran is striking, although limited sample size and age range limitations might have affected the comprehensive results of our study.

According to our preliminary study, the presence of Anelloviruses in the urine samples of asymptomatic children in Iran is striking, although limited sample size and age range limitations might have affected the comprehensive results of our study.

This study aims to compare the efficacy and toxicity of povidone-iodine (PI) 5%, polyhexamethylene biguanide (PHMB) 0.02%, and chlorhexidine 0.02% in patients undergoing phacoemulsification cataract surgery.

This single-center, randomized study was done on 330 patients who referred to Feiz hospital in Isfahan and scheduled for cataract surgery. They were assigned randomly to 1 of 3 groups of 110 eyes who received 1 drop of PI 5% in group 1, 1 drop of PHMB 0.02% in group 2 and 1 drop of chlorhexidine 0.02% in group 3. GSK J4 Histone Demethylase inhibitor Pre-operative Cultures samples were obtained without any topical application and it was repeated 5 min after use of antiseptic solutions. Cultures were obtained from the inferior conjunctival fornix, using sterile culture swabs while avoiding contact to the eyelids and lashes.

The numbers of colony-forming units (CFUs) did not differ significantly among the three groups (

= 0.149 and

= 0.260, respectively). After the intervention, CFUs numbers in the three groups were decreased with a significant difference in both blood and chocolate agars (

= 0.