To analyze the genetic cause of a hearing loss child with the Treacher Collins syndrome (TCS) phenotypes of malar hypoplasia, micrognathia, antimongoloid slanting palpebral fissures and cup ears.

Clinical analysis, hearing tests, chromosomal microarray analysis (CMA) and whole exome sequencing (WES) were performed on the family…[Read more]

XX-XX.].

To evaluate the likelihood of germline retinoblastoma in patients presenting with solitary unilateral retinoblastoma, based on age at presentation.

This retrospective case series of 482 consecutive patients presenting with solitary unilateral retinoblastoma analyzed the likelihood of germline retinoblastoma, defined as family…[Read more]

BACKGROUND Approximately 290 000 cases of in-hospital cardiac arrest occur annually, the majority of which are due to cardiac or respiratory causes. Cardiac arrest due to acute pulmonary embolism (PE) is associated with a 90% incidence of mortality and, if identified, it can be treated with systemic thrombolytics. Here, we describe a case in which…[Read more]

vel, linked to One Health and environmental initiatives, are urgently required.The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP Panel) assessed the safety of the recycling process Martogg Group (EU register number RECYC207), which uses the EREMA Advanced technology. The input is hot washed and dried poly(ethylene…[Read more]

The open-source tools provided in this article could allow other researchers to reproduce our results using their own datasets, with other IOL models, population settings, biometric devices, and measured, rather than calculated, posterior corneal radius of curvature or sum-of-segments axial lengths.

Our methodology achieved an accuracy…[Read more]

Photodynamic therapy (PDT) has been emerged as an alternative therapeutic modality in treatment of several malignant tumors. However, the therapeutic efficacy of PDT is often limited by the solubility of photosensitizers, tumor hypoxia and lack of target specificity to cancer cells. In this study, we developed a folate-conjugated fluorinated…[Read more]

5 (SD 3.8) years. Those with neuropathy had a significantly higher mean QTc compared to their counterparts. Mean QTc was significantly longer during hyperglycaemia. There was a significant positive association between QTc and time spent in hyperglycaemia. A negative association was found between QTc and time spent in hypoglycaemia. A functional…[Read more]

We hypothesize that the first signs of increased avian impact on root-associated fungi are the reduced diversity of sporocarps and the low presence and diversity of boletoid fungi in root tips.We examine reaction networks (CRNs) through their associated continuous-time Markov processes. Studying the dynamics of such networks is in general hard,…[Read more]

Plasma free VPA C

is a better predictor than peripheral blood mononuclear cell histone acetylation for brain H3 and H4 acetylation (r

​=​0.7189 for H3K27ac, r

​=​0.7189 for pan-H3ac, and r

​=​0.7554 for pan-H4ac; p​<​0.0001).

Up to 150​mg/kg VPA can be safely tolerated as 90-min intravenous infusion in a swine CA model. H…[Read more]

Plasma free VPA C

is a better predictor than peripheral blood mononuclear cell histone acetylation for brain H3 and H4 acetylation (r

​=​0.7189 for H3K27ac, r

​=​0.7189 for pan-H3ac, and r

​=​0.7554 for pan-H4ac; p​<​0.0001).

Up to 150​mg/kg VPA can be safely tolerated as 90-min intravenous infusion in a swine CA model. H…[Read more]

No significant associations were noted for neurologic outcomes, anaphylaxis, or cardiac events.

No major safety problems were detected following the first or second dose of the vaccine to prevent COVID-19 in the study cohort from December 18, 2020 through March 7, 2021.

No major safety problems were detected following the first or…[Read more]

Furthermore, stress analysis of the bile ducts shows that the WSS distribution is found mostly prevailing in the common hepatic duct and common bile duct areas. It is shown that when it is necessary to evaluate the bile flow dynamics in urgent medical situations, 1-way analysis is acceptable. Nevertheless, 2-way FSI provides more accurate data, if…[Read more]