Six of the seven patients reported stabilization of motor function or reduction in symptom severity. The changes in the assessed scores did not reach a significant level within this short time period. Conclusions Treating adult SMA patients with Nusinersen is feasible and most patients consider it beneficial. It demands a complex organizational…[Read more]

Both CD8+ T cells and NK cells contribute to the immune response against the protozoan Leishmania parasite. Both are able to generate IFN-γ and both display cytotoxic features. These features may enable them to not only contribute to parasite clearance but also to cause immune-mediated pathology. This pathology is evident, for example, in the…[Read more]

Durable treatments for intermittent claudication are needed.Diaphorina citri is a vector of “Candidatus Liberibacter asiaticus” (CLas), associated with citrus greening disease. D. citri exhibit at least two color morphotypes, blue and non-blue, the latter including gray and yellow morphs. Blue morphs have a greater capacity for long-distance…[Read more]

One of the most intriguing features of inhibitory synapses is the precision by which they innervate their target, not only at the cellular level but also at the subcellular level (i.e. axo-dendritic, axo-somatic, or axo-axonic innervation). LC-2 In particular, in the cerebellum, cortex, and spinal cord, distinct and highly specialized GABAergic…[Read more]