Exercise induced bronchoconstriction (EIB) is common and underdiagnosed phenomenon of yet largely unknown etiology. This study aimed to estimate prevalence of EIB in response to highly demanding skyscraper race and to test its association with race performance and hypothetical predisposing factors. Healthy participants (26 males, 8 females; 31.5…[Read more]

Conversely, overexpression of Cblb and Cbl was associated with significantly increased TrkA ubiquitination level, subsequently inactivating the NGF/TrkA downstream pathways Akt and Erk. Western blot and coimmunoprecipitation assays confirmed the direct interaction between TrkA and Cblb and TrkA and Cbl. In an in vivo experiment, exosomal…[Read more]

The clinical course of COVID-19 is very heterogeneous most infected individuals can be managed in an outpatient setting, but a substantial proportion of patients requires intensive care, resulting in a high rate of fatalities. We performed a biomarker study to assess the impact of prior infections with seasonal coronaviruses on COVID-19 severity.…[Read more]