this is one the very few studies focused on the impact of STIs on patient’s physical, psychological and sexual health. Physicians dealing with STIs should take into account the possible psychological consequences of the disease.

this is one the very few studies focused on the impact of STIs on patient’s physical, psychological and sexual health. Physicians dealing with STIs should take into account the possible psychological consequences of the disease.The indisputable contribution of dermatoscopy in early diagnosis of melanoma is widely recognized. EX 527 In the last quinquennium, new data concerning specific melanoma subtypes have come to light. The dermatoscopic morphology of superficial spreading melanoma (SSM) has been extensively investigated in the literature. Atypical network, irregular dots, irregular globules, irregular streaks and irregular blotch correspond to histopathologic alterations at the level of the junction, blue-white veil and atypical vessels suggest intradermal growth, whereas regression structures, negative network and white shiny streaks might reflect junctional or dermal alterations. The list of melanoma specific criteria has been recently updated to include features that typify early melanoma, such as irregular hyperpigmented areas and prominent skin markings and features seen in melanoma on sun damaged skin such as angulated lines. Nodular melanoma lacks most of the aforementioned criteria and is typified by the coexistence of blue and eccentric location of the suspicious area, negative network and gray angulated lines. Recent advances in knowledge on the dermatoscopic characteristics of peculiar subtypes of the tumor significantly enrich the diagnostic armamentarium of clinicians. The challenge of the forthcoming years is to better characterize biologically aggressive melanomas and to optimize the screening strategies so as to identify them.

Surgery is the main treatment for cutaneous melanoma including the primary melanoma as well as lymph node metastases. The recommended margins have changed over time. Similarly, indications for sentinel lymph node biopsy and complete lymph node dissection are constantly evolving as long as knowledge on the biological behavior of melanomas increases.

The current guidelines and the most relevant literature was reviewed to provide an update on the existing recommendations for surgical management of melanoma.

Wide excision margins are evidenced-based but not for all situations. Melanoma in situ requires 0.5-1 cm with increasing evidence for 1 cm particularly those presenting on the head and in the setting of chronic sun damage. Invasive melanomas need 1-2 cm margins, 2 cm for tumors thicker than 2 mm and some large tumors with >1-2 mm thickness and with a lentiginous growth pattern. Lentigo maligna, subungual melanoma, and acral lentiginous melanoma require surgical techniques with complete circumferentiadjuvant therapy; complete lymph node dissection is only relevant for regional disease control.The monoclonal anti-IL6 receptor antibody called Tocilizumab is widely used by rheumatologists for joint diseases. Its application in dermatology has mainly concerned scleroderma and Systemic Sclerosis in the last years. The most varied skin diseases treated with Tocilizumab, such as Psoriasis, Psoriatic Arthritis, Behcet’s Disease, Lupus, and the already mentioned Scleroderma up to multi-organ syndromes with skin involvement will be discussed. At the same time, there have been several side reactions to the drug involving the skin forcing careful skin monitoring during treatment. Despite the evidence currently available in the appropriate literature, there is no formal recommendation for any of these diseases to use Tocilizumab for therapeutic purposes. This review aims to collect all the main evidence on the use and involvement of the drug in dermatological practice in order to stimulate further research or hypothesize on possible therapeutic options.

It is not clear if soccer training affected the development of muscle strength positively in children. We hypothesize that soccer training could positively affect the isokinetic concentric muscle strength and anthropometric characteristics in different ages of adolescents of the same biological age.

A total of one-hundred and twenty-six (n=126) young soccer players (n=66) and untrained boys (n=60) throughout the developmental ages of 12, 14 and 16 years volunteered to participate in the study. Sexual maturation was classified according to Tanner’s stages. Soccer players, except from their school’s physical education program, participate also in a soccer training program. All participants underwent anthropometric measurements. The isokinetic-concentric peak torque values of the hamstrings (H) and quadriceps (Q), as well as the conventional strength ratios of HQ, were measured on an isokinetic dynamometer at angular velocities of 60, 180, and 300°·s-1.

Anthropometric differences in the same age group, between trained and untrained, were presented only for 12 year-olds (height, p<0.001 and BMI, p<0.01). Between groups, differences were observed in almost all anthropometric measurements, probably as result of development. The absolute isokinetic-concentric muscle strength was significantly higher (p<0.001) in the 12 and 16 years old trained group, compared to untrained, for the knee-flexors and knee-extensors. However, no significant differences were found between the 14 years old trained and untrained, for the muscle groups of Q and H. The HQ strength ratios did not differ between groups at all angular velocities.

The results of this study showed that systematic soccer training has a positive effect in the peripheral system, expressed as an increased lower limb muscle strength; specifically, Q and H.

The results of this study showed that systematic soccer training has a positive effect in the peripheral system, expressed as an increased lower limb muscle strength; specifically, Q and H.

CrossFit is becoming popular over the past few years, and various supplementation ways have been utilized by exercise physiologists to enhance CrossFit athletes’ performance. This study aimed to evaluate the effects of consuming pre-workout carbohydrateprotein supplements on CrossFit athletes’ performance.

Well-trained CrossFit athletes (8 men; 25.62 ± 3.02 years) were randomized to a singleblind, placebo controlled, crossover design (7-day washout) to performed six bouts of two CrossFit workouts Fight Gone Bad (FGB) and Cindy (CI). One hour and immediately before the onset of each bout, the subjects consumed carbohydrate-protein supplement in two ratios (22 or 31) or Placebo (P) FGB + 22, FGB + 31, FGB + P, CI + 22, CI + 31, and CI + P. To value the differentiation in performances, the performed each subject repetitions in FGB and CI were recorded in the bouts.

Repeated measure analysis of variance was used to analyze the data, and the level of significance set for the study was p ≤ 0.05. No significant difference was observed in the total number of repetitions performed in FGB (p= 0.