Substantial rescue of rare misprocessing mutations (S13F, R31C, G85E, E92K, V520F, M1101K, and N1303K), confined to MSD1, MSD2, NBD1, and NBD2 of CFTR, was also observed in airway epithelia, suggesting an allosteric correction mechanism and the possible application of Trikafta for patients with rare misfolding mutants of CFTR.Hidradenitis…[Read more]

Substantial rescue of rare misprocessing mutations (S13F, R31C, G85E, E92K, V520F, M1101K, and N1303K), confined to MSD1, MSD2, NBD1, and NBD2 of CFTR, was also observed in airway epithelia, suggesting an allosteric correction mechanism and the possible application of Trikafta for patients with rare misfolding mutants of CFTR.Hidradenitis…[Read more]

Atopic dermatitis (AD) is a common skin disease characterized by recurrent pruritic inflammatory skin lesions and defects of the skin barrier. Bacterial infection with Staphylococcus aureus contributes to increased severity of AD by compromising the barrier further. A microorganism component of Avène Thermal Spring Water, Aquaphilus dolomiae, is…[Read more]

Atopic dermatitis (AD) is a common skin disease characterized by recurrent pruritic inflammatory skin lesions and defects of the skin barrier. Bacterial infection with Staphylococcus aureus contributes to increased severity of AD by compromising the barrier further. A microorganism component of Avène Thermal Spring Water, Aquaphilus dolomiae, is…[Read more]

ary food in supermarkets.

The childhood obesity epidemic is a public health crisis. Most surveillance occurs in primary care, yet there is limited guidance for the detection and management of childhood obesity.

We sought to establish the overweight and obesity prevalence in children aged 4-11 years old in a single primary care centre.…[Read more]

ary food in supermarkets.

The childhood obesity epidemic is a public health crisis. Most surveillance occurs in primary care, yet there is limited guidance for the detection and management of childhood obesity.

We sought to establish the overweight and obesity prevalence in children aged 4-11 years old in a single primary care centre.…[Read more]

69, 95% CI 0.61-0.75, P<0.001) with sensitivity and specificity of 75% and 72.4%, respectively. Using Pearson’s correlation analysis, significant positive correlation between sclerostin and severity of CT was found (r=0.29, P=0.001).

High circulating sclerostin is associated with the presence and severity of CT in postmenopausal females.…[Read more]