This opinion paper expanded on the WHO “six-step approach to optimal pharmacotherapy,” by detailed exploration of the underlying pharmacological andpathophysiological principles. This exercise led to the identification of a large number of domains of research that should be addressed to make clinicalpharmacology progress toward “precision clinical…[Read more]

The number of stem cells collected from patients who received G+plerixafor was higher than those who received other regimens (median CD34+ cells harvested/day were 2.90 for G-CSF, 2.13 for G+CY, and 4.63 for G+plerixafor, ×106/kg body weight, P less then 0.01). Our results show that plerixafor enables efficient apheresis.This study investigated…[Read more]