miR-27a augmentation via tail-vein injection of miR-27a mimic in high cholesterol diet-fed Apoe -/- mice shows down-regulation of hepatic Hmgcr and plasma cholesterol levels. Pathway and gene expression analyses show that miR-27a also targets several other genes (apart from Hmgcr) in cholesterol biosynthesis pathway. Taken together, miR-27a…[Read more]

OBJECTIVES To evaluate effectiveness of Milieu Therapy in reduction of conflict and containment rates among schizophrenia patients. METHODS This study utilized quasi experimental non-equivalent control group pre-post design. HDM201 MDMX inhibitor One hundred schizophrenia patients admitted in acute psychiatric wards were non-randomly assigned to…[Read more]

tual disability and autism.

These results represent a unique opportunity for the development of a specific class of compounds for treating 7Dup and other forms of intellectual disability and autism.

Obtaining reliable estimates of the health-related quality of life (HR-QoL) of people with predementia Alzheimer’s disease [AD] (preclinical or…[Read more]