The polymorphic drug-metabolizing enzyme CYP2D6, which is responsible for the metabolism of most psychoactive compounds, is expressed not only in the liver, but also in the brain. The effects of its marked genetic polymorphism on the individual capacity to metabolize drugs are well known, but its role in metabolism of neural substrates affecting…[Read more]

This volume-outcome relationship was also found to specifically affect the complication and recurrence rates for thyroid cancer patients undergoing surgery, especially for individuals with advanced stage disease.

The heterogeneity in cut-offs used for characterizing surgeons as high versus low volume, and also in subsequent patient outcome…[Read more]

Women’s aims subsequently moved to self-actualisation and economic and personal independence which required professional training, internships, and social support. Although satisfying the majority of the women’s expectations, other important needs (e.g., economic support or legal services) were poorly addressed, and cooperation with other services…[Read more]

lTrials.gov Identifier NCT03357328 . BTK inhibitor Registered 29 November 2017 – Retrospectively registered.

ClinicalTrials.gov Identifier NCT03357328 . Registered 29 November 2017 – Retrospectively registered.

The rapidly aging societies worldwide and in Singapore present a unique challenge, requiring an integrated multidisciplinary…[Read more]

058) and strength of the magnetic field (Q4; p=0.062) in seizure control remained unclear. The median seizure-free period (Q6) was 0.643 (0.569-0.726) and 0.467 (0.385-0.566) for the one- and the two-year follow up.

LITT seems to offer a viable alternative to resective surgery, with a moderate efficacy and enduring results. Higher ablation…[Read more]

Neuroimaging measures of Alzheimer’s disease (AD) include grey matter volume (GMV) alterations in the Default Mode Network (DMN) and Executive Control Network (ECN). Small-vessel cerebrovascular disease, often visualised as white matter hyperintensities (WMH) on MRI, is often seen in AD. However, the relationship between WMH load and GMV needs…[Read more]

The Hg2+ and Ag+ ions can be masked by adding ethylenediaminetetraacetate and Cl-, respectively, to the Hg2+ and Ag+ samples. The good sensitivity, high reproducibility, and excellent selectivity of these nanosensors were also demonstrated. Furthermore, detection of Hg2+ in living breast cancer cells at the subcellular level is possible, thanks to…[Read more]

07, 95% CI 1.03-1.12).

High inotrope score post-HTx was observed in recipient congenital heart disease and was associated with a higher risk of mortality and acute kidney injury.

High inotrope score post-HTx was observed in recipient congenital heart disease and was associated with a higher risk of mortality and acute kidney injury.…[Read more]

2±20.3%; placebo, 50.0±21.9%; mean difference, 8.20%; 95% CI, 0.43-15.9%; P=.038). Dextrose gel did not increase recurrent or severe episodes of low glucose concentrations and did not increase the peak glucose concentration. These effects were similar for all trial dosages.

Low glucose concentrations were common in infants at risk of h…[Read more]

Lipoproteins are multi-molecule assemblies with the primary function of transportation and processing of lipophilic substances within aqueous bodily fluids (blood, cerebrospinal fluid). Nevertheless, they also exert other physiological functions such as immune regulation. In particular, neurons are both sensitive to uncontrolled responses of the…[Read more]

Despite the central role of auto-(recurrence of T1D) and allo-(T-cell mediated rejection) immune cellular responses, the latter are not directly monitored in routine. In striking contrast, there have been undisputable progresses in monitoring of auto and alloantibodies. Bcl-2 phosphorylation Except for pancreas recipients in whom anti-donor HLA…[Read more]