Triggered methods led to increased percentages of MS2 spectra and additional MS2 spectra for compounds with a structural alert. Application to surface water samples resulted in additional MS2 spectra of potentially toxic compounds, facilitating more confident identification and emphasizing the method’s potential to improve monitoring studies.Cinnamate-based polyesters were synthesized, including poly(4-hydroxycinnamic acid), poly(4-hydroxy-3-methoxycinnamic acid), poly(3-hydroxycinnamic acid) (P3HCA), and hyperbranched poly(3,4-dihydroxycinnamic acid) (PdHCA). These materials were further processed into hard and dry membranes by casting and underwent photoreactions by ultraviolet (UV) light. The photodeformation behavior of the linear and hyperbranched polyester containing membranes with cinnamate derivatives in the main chain was observed macroscopically and microscopically. The PdHCA and P3HCA membranes were amorphous and exhibited photodeformations. The PdHCA surface visibly contracts, which is a typically observed phenomenon in photoresponsive polymers; however, the P3HCA surface showed a unique photoexpansion behavior. Time-resolution infrared spectroscopy of the P3HCA film revealed trans-to-cis isomerism in the polymer main chains that bent convexly as a result of photoexpansion of the UV-irradiated regions. Furthermore, photomasking created a micropattern on the P3HCA film, which supported the photoexpansion mechanism of the P3HCA film.Kidney tissue engineering and regeneration approaches offer great potential for chronic kidney disease treatment, but kidney tissue complexity imposes an additional challenge in applying regenerative medicine for renal tissue regeneration. In this study, a porous pneumatic microextrusion (PME) composite scaffold consisting of poly(lactic-co-glycolic acid) (PLGA, P), magnesium hydroxide (MH, M), and decellularized porcine kidney extracellular matrix (kECM, E) is functionalized with bioactive compounds, polydeoxyribonucleotide (PDRN), and tumour necrosis factor-α (TNF-α)/interferon-γ (IFN-γ)-primed mesenchymal stem-cell-derived extracellular vesicles (TI-EVs) to improve the regeneration and maintenance of a functional kidney tissue. The combination of PDRN and TI-EVs showed a significant synergistic effect in regenerative processes including cellular proliferation, angiogenesis, fibrosis, and inflammation. In addition, the PME/PDRN/TI-EV scaffold induced an effective glomerular regeneration and restoration of kidney function compared to the existing PME scaffold in a partial nephrectomy mouse model. Therefore, such an integrated bioactive scaffold that combines biochemical cues from PDRN and TI-EVs and biophysical cues from a porous PLGA scaffold containing MH and kECM can be used as an advanced tissue engineering platform for kidney tissue regeneration.Robenidine is a veterinary drug used in the poultry industry to treat coccidiosis caused by parasites in the Eimeria genus. Though this compound and related aminoguanidines have recently been studied in other pathogens, the chemotype has not been systematically explored to optimize antimalarial activity despite the close genetic relationship between Eimeria and Plasmodium (both are members of the Apicomplexa phylum of unicellular, spore-forming parasites). In this study, a series of aminoguanidine robenidine analogues was prepared and tested in vitro against Plasmodium falciparum, including multidrug-resistant strains. Selected compounds were further evaluated in vivo against murine Plasmodium yoelii in mice. selleck products Iterative structure-activity relationship studies led to the discovery of 1, an aminoguanidine with excellent activity against drug-resistant malaria in vitro and impressive in vivo efficacy with an ED50 value of 0.25 mg/kg/day in a standard 4-day test.The development of rechargeable Zinc-ion batteries (ZIBs) has been hindered by the lack of efficient cathode materials due to the strong binding of divalent zinc ions with the host lattice. Herein, we report a strategy that eliminates the participation of Zn2+ within the cathode chemistry. The approach involves the use of composite cathode materials that contain Zn halides (ZnCl2, ZnBr2, and ZnI2) and carbon (graphite or activated carbon), where the halide ions act both as charge carriers and redox centers while using a Zn2+-conducting water-in-salt gel electrolyte. The use of graphite in the composite electrode produced batterylike behavior, where the voltage plateau was related to the standard potential of the halogen species. When activated carbon was used in the composite, however, the cell acted as a hybrid Zn-ion capacitor due to the fast, reversible halide ion electrosorption/desorption in the carbon pores. The ZnX2-activated carbon composite delivers a capacity of over 400 mAh g-1 and cell energy density of 140 Wh kg-1 while retaining over 95% of its capacity after 500 cycles. The halogen reaction mechanism has been elucidated using combinations of electrochemical and in situ spectroscopic techniques.The presence of antibodies against endemic coronaviruses has been linked to disease severity after SARS-CoV-2 infection. Assays capable of concomitantly detecting antibodies against endemic coronaviridae such as OC43, 229E, NL63, and SARS-CoV-2 may help to elucidate this question. We developed a serum screening platform using a bead-based Western blot system called DigiWest, capable of running hundreds of assays using microgram amounts of protein prepared directly from different viruses. Characterization of the immunoassay for detection of SARS-CoV-2 specific antibodies revealed a sensitivity of 90.3% and a diagnostic specificity of 98.1%. Concordance analysis with the SARS-CoV-2 immunoassays available by Roche, Siemens, and Euroimmun indicates comparable assay performances (Cohen’s κ ranging from 0.8874 to 0.9508). Analogous assays for OC43, 229E, and NL63 were established and combined into one multiplex with the SARS-CoV-2 assay. Seroreactivity for different coronaviruses was detected with high incidence, and the multiplex assay was adapted for serum screening.As a passive cooling strategy, radiative cooling is becoming an appealing approach to dissipate heat from terrestrial emitters to the outer space. However, the currently achieved cooling performance is still underperforming due to considerable solar radiation absorbed by the emitter and nonradiative heat transferred from the surroundings. Here, we proposed a mechanically robust and spectrally selective convection shield composed of nanoporous composite fabric (NCF) to achieve daytime subambient radiative cooling. By selectively reflecting ∼95% solar radiation, transmitting ∼84% thermal radiation, and suppressing the nonradiative heat transferred from warmer surroundings, the NCF-based radiative cooler demonstrated an average daytime temperature reduction of ∼4.9 °C below the ambient temperature, resulting in an average net radiative cooling power of ∼48 W/m2 over a 24 h measurement. In addition, we also modeled the potential cooling capacity of the NCF-based radiative cooler and demonstrated that it can cover the cooling demands of energy-efficient residential buildings in most regions of China.