Additionally, nanoparticles can provide a platform for the co-delivery of siRNAs and anti-tumor drugs, resulting in decreased growth and migration of PCa cells. The efficacy, specificity, and delivery of siRNAs are comprehensively discussed in this review to direct further studies toward using siRNAs and their nanoscale-delivery systems in PCa…[Read more]

33% (n=47) responded to postal questionnaires; high levels of pain, symptom chronicity and disability were ubiquitous but self-reported mental health diagnoses and PHQ-15 were higher for SN patients. CONCLUSIONS Conflicting data suggests further research is needed to investigate the prevalence of mental illness and somatic symptoms in SN cases. SN…[Read more]

However, during the rainy season, the surface water in the area was affected by saltwater intrusion, with salinity up to 4.1‰. Discriminant analysis was applied to study the differences among the water groups. As a result, the treated and tap water were separated from the others.To gain greater insights into impacts of bio-carriers on the fate a…[Read more]

DHM treatment restored ATP and gephyrin expression, GABAergic transmission and synaptic function, as well as decreased anxiety-like behavior. Our findings indicate broader roles for DHM in anxiolysis, GABAergic neurotransmission, and synaptic function. Collectively, our data suggest that reduction in intracellular ATP and gephyrin contribute to…[Read more]