Protein kinases and GTPases are the two major molecular switches that regulate much of biology, and both of these domains are embedded within the large multi-domain Leucine-Rich Repeat Kinase 2 (LRRK2). Mutations in LRRK2 are the most common cause of familial Parkinson’s disease (PD) and are also implicated in Crohn’s disease. The recent…[Read more]

Numerical simulations of different load cases suggest that ignoring the undulations of fibres and their non-uniform cross-sections only moderately affects the passive response of the tissue in tensile and compressive modes, but can become crucial when predicting the response to generic loads and activation.Recent reviews by the clinical bone…[Read more]

L.P. Li, J.W. Liang and H.J. Fu. An update on the association between traumatic brain injury and Alzheimer’s disease Focus on Tau pathology and synaptic dysfunction. NEUROSCI BIOBEHAV REVXXX-XXX,2020.-Traumatic brain injury (TBI) and Alzheimer’s disease (AD) are devastating conditions that have long-term consequences on individual’s cognitive…[Read more]