Hair analysis has been an important approach in evaluating population exposure to various environmental factors. To meet the requirements of human environmental epidemiology studies, we aimed to develop an efficient method for simultaneous analysis of various metal(loid)s and some typical environmental halogenated endocrine disrupting chemicals…[Read more]

To investigate whether serum-soluble PD-L1 (sPD-L1) is a potential biomarker for identifying sepsis. This study enrolled 64 septic patients, 29 patients with acute appendicitis, 33 patients with acute pancreatitis and 30 healthy volunteers. Sepsis was defined according to the Sepsis 3.0 criteria.[1] The associated clinical parameters were…[Read more]

The use of aptamers in bioanalytical and biomedical applications exploits their ability to recognize cell surface protein receptors. Targeted therapeutics and theranostics come to mind in this regard. selleck chemicals However, protein receptors occur on both cancer and normal cells; as such, aptamers are now taxed with identifying high vs. low…[Read more]

e hurricane, and a focus on access to medications, infection control, and injury prevention/management after a disaster needs to be prioritized during disaster response.

Infection treatment and chronic disease management were important medical needs facing patients seeking care at FMS Manatí after Hurricane Maria. These findings suggest that…[Read more]

However, the real prediction uncertainty is extreme and is discussed in the essay presented here. Copyright © 2020 Rychlik and Schmitt-Kopplin.Increasing levels of bacterial resistance to many common and last resort antibiotics has increased interest in finding new treatments. The low rate of approval of new antibiotics has led to the search for…[Read more]

Hypoxia is one of the major stresses in aquaculture animals. Recently, we reported that hypoxia disrupts the endocrine system and inhibits testicular function of oriental river prawns (Macrobrachium nipponense), but the molecular mechanism of testes responded to hypoxia remains largely unknown. In the present study, we aimed to integrate whole…[Read more]

Background Giant axonal neuropathy (GAN; ORPHA 643; OMIM# 256850) is a rare, hereditary, pediatric neurodegenerative disorder associated with intracellular accumulations of intermediate filaments (IFs). Validation of therapeutic efficacy and viral vector delivery systems with GAN knockout (KO) mouse models has provided the springboard for the…[Read more]

PURPOSE To create a dose response model that predicts lung ventilation change following radiation therapy, and examine the effects of out-of-phase ventilation. METHODS The dose response model was built using 27 human subjects who underwent radiation therapy (RT) from an IRB-approved trial. For each 4DCT, two ventilation maps were created by…[Read more]

We further discuss underlying molecular regulators determining fate specifications of NCSCs, suggesting a regulatory network including NF-κB and NC-related transcription factors like SLUG and SOX9 accompanied by Wnt- and MAPK-signaling to orchestrate NCSC stemness and differentiation. In summary, adult NCSCs show a broad heterogeneity on the…[Read more]

© 2020 Wiley Periodicals, Inc.Controlled synthesis of single-walled carbon nanotubes (SWNTs) is important for further application of carbon nanotubes. SWNT horizontal arrays with specific chirality can be enriched using carbide solid catalysts on substrates. However, it remains a big challenge to increase the production by continuous loading the…[Read more]

© 2020 Wiley Periodicals, Inc.Controlled synthesis of single-walled carbon nanotubes (SWNTs) is important for further application of carbon nanotubes. SWNT horizontal arrays with specific chirality can be enriched using carbide solid catalysts on substrates. However, it remains a big challenge to increase the production by continuous loading the…[Read more]

ties. Recent advancements in 3D printing have revolutionized biomedical engineering by enabling the manufacture of complex and functional devices in a low-cost, customizable, and small-batch fabrication manner. Soft elastomers are particularly important for biomedical applications because they can provide similar mechanical properties as tissues…[Read more]