The post-monsoon cyclone produced a substantial increase in total nitrogen (TN) and total phosphorous (TP), a large drop in salinity, CDOM, and Chl-a. In contrast, after the pre-monsoon cyclone, TN and TP did not show any such hike, no substantial change in salinity and CDOM either, and only a slight increase in Chl-a was observed. We found that the controlling factor in determining the impact of a cyclone is the rate and duration of freshwater discharge to the lagoon, which is normally a strong pulse for pre-monsoon and a continued high flow for post-monsoon cyclones. We conclude that the antecedent conditions of the lagoon and the watershed at the time of a cyclone’s landfall is a key criterion in determining the impact. The combined use of satellite data and field data was proved critical to capture the overall impact of cyclones on the hydrological characteristics of the monsoon-regulated coastal lagoon.Eliminating the critical knowledge gaps of perfluorooctanoic acid (PFOA) effects in planta is the imperative target to accomplish accurate and meaningful exposure-risk assessment in the environment. Here, we investigated the effect of environmentally relevant concentrations of PFOA on the oxidative stress and metabolic regulation in lettuce (Lactuca sativa) root. Under the exposure to 5 and 50 μg/L PFOA for 10 days, 137.5 and 1275.0 ng PFOA/g dry weight were accumulated to roots, respectively. H2O2, the dominant reactive oxygen species, was slightly over-generated by 4.7%-9.5%. No signs of oxidative damage, such as lipid peroxidation, cell membrane integrity and soluble protein content, were observed. To deal with PFOA stress, the activities of ascorbate peroxidase and peroxidase and the contents of glutathione were dose-dependently up-regulated. Partial least-squares discriminant analysis revealed metabolite profiles were significantly altered by PFOA, involving the primary metabolism (e.g., sucrose, glucose, fructose-6-phosphate, methionine, γ-aminobutyric acid), and the biosynthesis of (poly)phenol (e.g., shikimate, naringenin) and alkaloid (e.g., geranyl diphosphate, dopamine). Our findings showed that environmentally relevant concentrations of PFOA significantly perturbed metabolisms in plant roots albeit no remarkable cell damage was induced.Solid-waste coal gangue (CG) mixed with cement as underground backfilling material is widely applied in coal mines throughout China. However, this material can pollute the environment during its production, preparation, and transportation, which is mainly caused by cement. As a cement-free eco-friendly technology, microbially induced carbonate precipitation (MICP) technology can produce biomineralization products to consolidate loose grains, and the microbial growth environment is adapted to underground temperature with no pollution. CDK inhibition To this end, this study gets the Bacillus pasteurii with special resistance by strain domestication, proposes a CG-based bio-mineralized underground backfilling material without using cement, and analyses the characteristics of it from macro- to microscopic perspectives by dissolution test, scanning electron microscopy (SEM), Energy-dispersive spectroscopy (EDS) and X-ray diffraction (XRD). The results indicate that strain domestication leads to B. pasteurii, which can withstand CG leaching solution and 1 M urea simultaneously. This satisfies the basic requirements of CG based mineralized material. Through the circulation perfusion method, the intact CG based biomineralized specimens are obtained. Macroscopically, the bacteria bind gangue grains into a whole with high biomineral content (11.66%). The utilization rate of mineralizing solution is up to 66.82% which makes good use of raw materials. Microscopically, a new crystal formation is observed, and CG particles are consolidated well where the crystals precipitate to fill the pores and bind the particles together. Hence this method has a significant influence on the deposition of biominerals. Meanwhile the biomineralization improves the microstructure considerably and bonds the CG particles as a whole. A comprehensive analysis of the test results shows that, from an environment viewpoint, the preliminary study of new CG based bio-mineralized material is successful.Persistent organic pollutants (POPs) are ubiquitous contaminants with adverse health effects in the ecosystem. One of such effects is endocrine disruption in humans and wildlife even at background exposure concentrations. This study assessed maternal breastmilk concentrations of POPs; brominated flame retardants (BFRs), polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs), and the potential health risks posed to the nursing infants. We also evaluated the association of these POPs with total 3,3′,5-triiodo-L-thyronine (T3), L-thyroxine (T4), and 3,3′,5′-triiodo-L-thyronine (rT3) levels measured in human breast milk. Thirty breastmilk samples were collected from Kampala, Uganda between August and December 2018. Hexabromobenzene was not detected while the maximum level of 2,2′,4,4′,5,5′-hexabrombiphenyl was 64.7 pg/g lw. The median levels of total indicator PCBs, PBDEs, dioxin-like PCBs, and PCDD/Fs in the samples were 159 pg/g lw, 511 pg/g lw, 1.16 pg TEQ/g lw, and 0.4 pg TEQ/g lw, respectively. These levels were lower than those reported in other countries. Owing to their bio accumulative nature, PCBs -81, -169, and ∑PCDD/Fs increased with increase in maternal age. Estimated dietary intakes for dioxin-like PCBs and PCDD/Fs were lower than those reported elsewhere but were higher than the WHO tolerable daily intakes suggesting potential health risks to nursing infants. In adjusted single pollutant models, PCB-126, PCB-169, and ∑PCBTEQ were negatively associated with T3, while 1,2,3,4,5,7,8-HpCDF was positively associated with rT3. Although these associations did not persist in multipollutant models, our findings suggest potential thyroid hormone disruption by POPs in mothers. This may reduce the levels of thyroid hormones transferred from the mother to the neonates and, hence, adversely influence infant growth. A temporal study with a bigger sample size is required to corroborate these findings.