In the stage B, the RLAD (AUC, 0.99; cutoff, ≥1.8; sensitivity, 100%; specificity 93%) performed better than VLAS (AUC, 0.90; cutoff, ≥2.4; sensitivity, 66%; specificity 100%) and VHS (AUC, 0.89; cutoff, ≥10.7; sensitivity, 88%; specificity 83%) in the detection of dogs fulfilling the echocardiographic criteria for stage B2.

VLAS and RLAD…[Read more]

Consistent with the in vitro data, our patient-derived CRC xenograft model showed that inhibition of NPM1 suppressed tumor growth and attenuated AKT signaling in vivo. Moreover, LY294002, an inhibitor of the PI3K/AKT pathway, restored the chemosensitivity of CRC cells expressing high levels of NPM1. The findings that NPM1’s expression in CRC…[Read more]

In addition, treatment of A2780cis cells with 5-aza-2′-deoxycytidine, a DNA-demethylating agent, restored GS expression and reduced CDDP resistance. Akt inhibitor In contrast, GS knockdown in CDDP-sensitive A2780 cells induced CDDP resistance.

The results indicate that upregulation of GSH synthesis from glutamine via DNA…[Read more]

Useful biomarkers for metabolic syndrome have been insufficient. We investigated the performance of serum milk fat globule-EGF factor-8 (MFG-E8), the key mediator of inflammatory pathway, in diagnosis of metabolic syndrome.

Subjects aged between 30 and 64 years were prospectively enrolled in the Seoul Metabolic Syndrome cohort. Serum…[Read more]