Dendritic cells (DCs) possess intrinsic cellular defense mechanisms to specifically inhibit HIV-1 replication. In turn, HIV-1 has evolved strategies to evade innate immune sensing by DCs resulting in suboptimal maturation and poor antiviral immune responses. We previously showed that complement-opsonized HIV-1 (HIV-C) was able to efficiently…[Read more]

Inhibition of Notch signaling has been recently demonstrated to promote beige adipocyte biogenesis. However, most γ-secretase inhibitors (GSIs) used to achieve pharmacological inhibition of Notch signaling are at the basic research or preclinical stage, limiting the translation of fundamental findings into clinical practice. This present study…[Read more]

Based on these findings, we caution policy makers not to make their decisions solely based on the guidance of the basic reproduction number only, which clearly could cause trouble.The proposed work utilizes support vector regression model to predict the number of total number of deaths, recovered cases, cumulative number of confirmed cases and…[Read more]

Based on these findings, we caution policy makers not to make their decisions solely based on the guidance of the basic reproduction number only, which clearly could cause trouble.The proposed work utilizes support vector regression model to predict the number of total number of deaths, recovered cases, cumulative number of confirmed cases and…[Read more]

Transfer rates were similar for viper’s bugloss (0.05%) but lower for common groundsel (0.01%). Only a small portion of the administered PAs was quantified in milk, urine and faeces, with an overall balance of 4.5%, 2.9% and 5.8%, for ragwort, common groundsel and viper’s bugloss, respectively. Samples taken from the rumen indicated that the…[Read more]