atients. These data underline the need for further larger epidemiological analysis and public health interventions.

To evaluate the curative effect of hemoperfusion therapy on central nervous system injury in patients with 2,4-dichlorophenoxyacetic acid poisoning.

A total of 60 patients with 2,4-dichlorophenoxyacetic acid poisoning were enrolled in this study. They were admitted to the Emergency Department of Qinghai Provincial People’s Hospital from 2015 to 2018 and were randomly divided into two groups by random number table method. One group was control group (routine treatment group), and the other group was the treatment group (hemoperfusion therapy was added on the basis of routine treatment). Glasgow coma score (GCS), APACHE II score, and MMSE score were used to evaluate the effects before treatment and 7 days after treatment. The results were statistically analyzed.

After treatment, GCS in the treatment group was higher than that in the control group, while APACHE II score was lower than that in the control group, and MMSE score was significantly higher than that in the control group, with statistically significant difference (p<0.05). The effective rate in the control group was only 26.67%, and that in the treatment group was 86.67%, with statistically significant difference (c2=19.62, p<0.001).

Hemoperfusion therapy can promote the recovery of central nervous system in patients with 2,4-dichlorophenoxyacetic acid poisoning, reduce the injury of other organs, and significantly reduce the mortality of patients.

Hemoperfusion therapy can promote the recovery of central nervous system in patients with 2,4-dichlorophenoxyacetic acid poisoning, reduce the injury of other organs, and significantly reduce the mortality of patients.

Inositol is a carbocyclic sugar polyalcohol. By epimerization of its hydroxyl groups, nine possible stereoisomers can be generated, two of major physiological and clinical relevance myo-inositol and D-chiro-inositol. Myo-inositol and D-chiro-inositol are normally stored in kidney, brain and liver and are necessary for functions, such as signal transduction, metabolic flux, insulin signaling, regulation of ion-channel permeability, stress response and embryo development. In this narrative review, we summarize the mechanisms by which myo-inositol and D-chiro-inositol can be synthesized and absorbed and their possible role in the etiopathogenesis of neural tube defects.

We performed an online search in the PubMed database using the following keywords “inositol”, “D-chiro-inositol”, “myo-inositol”, “neural tube defects and inositol”.

Inositol requirements are partly met by dietary intake, while the rest is synthesized endogenously. Inositol deficiency may be involved in the pathogenesis of diseases, such asinositol metabolism may provide important information for the clinical management of these conditions.

Andrographolide and its derivatives have many functions, such as anti-infection, anti-tumor, neuroprotection, and immune regulation. However, the gastrointestinal protective effects, especially gastrointestinal tumors, and inflammation-related diseases of andrographolide and its derivatives have not been well summarized and discussed. In this review, we aimed to summarize and discuss the pharmacological effects and underlying mechanisms of andrographolide and its derivatives in gastrointestinal protection, with a view to revealing more possibilities of andrographolide and its derivatives in gastrointestinal diseases prevention therapy.

The data in this review are searched and selected from PubMed with the keywords Andrographolide and Andrographolide derivatives, and relevant data with gastrointestinal protection are extracted and discussed.

Andrographolide and its derivatives have prophylactic and therapeutic effects in gastrointestinal disorders such as GU, gastric cancer, colorectal cancer, and inflammatory bowel disease.

Andrographolide and its derivatives are effective compounds for gastrointestinal protection.

Andrographolide and its derivatives are effective compounds for gastrointestinal protection.Integrative Medicine Research Group (IMRG) presents a new conference scene about the “Ageing and osteoarticular system for healthy ageing” within a multidisciplinary approach of Integrative Medicine.

Methotrexate (MTX) is widely used in the treatment of rheumatic and non-rheumatic disorders. Severe adverse effects are often associated with therapeutic errors, such as daily intake rather than weekly intake. Among them, the risk of bowel perforation is extremely rare (0.1%). We describe a case of bowel perforation, occurred following daily intake of MTX.

A 68-year-old man was prescribed to take MTX 7,5 mg orally once a week, while waiting for switch to abatacept for a recent reactivation of rheumatoid arthritis. After 10 days he started having pharyngodynia, hematochezia and general malaise. At medical examination he presented oral and nasal mucositis; moreover, blood exams showed thrombocytopenia. The anamnesis revealed that he had been taken the prescribed dosage of MTX daily, instead of weekly. Therapy with Lederfolin 1000 mg (mg/m²/die) and urine alkalinization started. After 7 days of hospitalization, there was an abrupt worsening of clinical conditions and an emergency CT scan revealed millimetric gas bubbles indicating bowel perforation. The patient underwent an emergency exploratory laparotomy that resulted in peritoneal toilette and sigma resections. Anatomopathological findings were suggestive of MTX poisoning.

The patient was discharged on the 17th day in good clinical condition.

The patient was discharged on the 17th day in good clinical condition.

Anlotinib, a novel tyrosine kinase receptor inhibitor (TKI), targets multi-targets, including vascular endothelial growth factor receptor (VEGFR). Increasing evidence suggests that anlotinib exhibits effective anti-tumor activity in various cancer types, such as liver cancer. However, the biological function of anlotinib in the treatment of colorectal cancer (CRC) remains largely unknown. This investigation aims to investigate the function and possible molecular mechanism of anlotinib in CRC therapy.

Human colorectal cancer cells (HCT-116 and LOVO) were cultured and treated with anlotinib alone or combined with cisplatin (DDP). Thereafter, CCK8 assay, CyQUANT NF assay, and colony formation were used to determine the cytotoxicity property and cell proliferation of colorectal cancer. Acetohydroxamic To evaluate the invasion and metastasis of colorectal cancer cells, we conducted wound healing and trans-well assay. Hoechst33342 fluorescence staining and Flow Cytometry analysis were applied for apoptosis detection. Real-time qPCR and Western blot were used to measure the mRNA or protein level.