Growth differentiating factor-15 (GDF15) is an emerging target for the treatment of obesity and metabolic disease partly due to its ability to suppress food intake. GDF15 expression and secretion are thought to be regulated by a cellular integrated stress response, which involves endoplasmic reticulum (ER) stress. AMPK is another cellular stress…[Read more]

75, 95% CI -1.36 to -0.14; P=0.02), ICIQ-SF score (MD -3.79, 95% CI -5.89 to -1.69; P=0.0004), PFME (MD 1.93, 95% CI 0.99 to 2.87; P<0.0001) and pad weight (MD -1.40, 95% CI -1.70 to -1.00; P<0.00001).

Current evidence indicated that APFMT might facilitate the recovery of UI after RP according to intermediate-term advantages over CPFMT in…[Read more]