It appears a favourable outcome was related to early PE diagnosis and a multimodal therapeutic approach.

Physicians in the ER should be warned about extremely high D-dimer measurements and severe oxygen desaturation as possible markers of severe COVID-19 pneumonia in patients with high-clinical suspicion of PE. Although ESC guidelines…[Read more]

Silencing the RRM2 gene led to significantly greater cell survival (80%) compared with the control group (

 = .003), whereas overexpression of the RRM2 increased viral oncolysis by 33% (

 < .001).

Our results show that the oncolytic effects of MYXV correlate directly with RR expression levels and are enhanced in STS cell lines w…[Read more]

Silencing the RRM2 gene led to significantly greater cell survival (80%) compared with the control group (

 = .003), whereas overexpression of the RRM2 increased viral oncolysis by 33% (

 < .001).

Our results show that the oncolytic effects of MYXV correlate directly with RR expression levels and are enhanced in STS cell lines w…[Read more]

With the waste collection efficiency in Harare at about 72.4%±7.5%, the city collects approximately 170, 385, 600±33 384 209 kg of HSW annually. All the collected HSW is disposed of in the city’s major MSW dumpsite called Pomona and only about 23, 498, 400±3, 988, 817 kg MSW is recovered annually with the average recovery efficiency at around 9.…[Read more]

Pazopanib, a multitargeted tyrosine kinase inhibitor, is recommended as the standard treatment for refractory soft tissue sarcoma (STS). However, there are comparatively few molecular determinants for predicting pazopanib efficacy. Based on correlative studies regarding the predictive impact of PD-L1, we investigated the clinical relevance of…[Read more]

Pazopanib, a multitargeted tyrosine kinase inhibitor, is recommended as the standard treatment for refractory soft tissue sarcoma (STS). However, there are comparatively few molecular determinants for predicting pazopanib efficacy. Based on correlative studies regarding the predictive impact of PD-L1, we investigated the clinical relevance of…[Read more]

Animal studies have shown that high-frequency stimulation (HFS) of peripheral C-fibres induces long-term potentiation (LTP) within spinal nociceptive pathways. The aim of this replication study was to assess if a perceptual correlate of LTP can be observed in humans. In 20 healthy volunteers, we applied HFS to the left or right volar forearm.…[Read more]

in hSCAPs. All herbal extracts tested in this study exhibited antibacterial activity comparable to NaClO against bacterial infections, while the strongest bacteriostatic effect was shown in the treated group. These extracts had much weaker effects on the proliferation and migration of hSCAPs and hPDLFs as calculated by the CCK-8 assay against…[Read more]

Identifying when hominins first produced Lomekwian, Oldowan, and Acheulean technologies is vital to multiple avenues of human origins research. Yet, like most archaeological endeavors, our understanding is currently only as accurate as the artifacts recovered and the sites identified. Here we use optimal linear estimation (OLE) modelling to…[Read more]

The cluster ofdifferentiation 47 (CD47)-signal regulatory protein alpha (SIRPα) signaling pathway plays important roles in immune homeostasis and tissue inflammatory response. Activation of the Hedgehog/smoothened (SMO)/GLI family zinc finger 1 (Gli1) pathway regulates cell growth, differentiation, and immune function. However, it remains unknown…[Read more]