3 ± 15.6 nM). The administration of PSM0537 in vitro and in vivo could dramatically inhibit cell proliferation, invasion, and metastasis. Collectively, our findings reveal that the AF1Q-TCF4 transcriptional complex controls the expression of COX2 and that targeting the AF1Q-TCF4 interaction with PSM0537 could inhibit tumor cell growth and…[Read more]

Skeletal muscle myofibers are large and elongated cells with multiple and evenly distributed nuclei. Nuclear distribution suggests that each nucleus influences a specific compartment within the myofiber and implies a functional role for nuclear positioning. Compartmentalization of specific mRNAs and proteins has been reported at the neuromuscular…[Read more]

The concept of open access journals was introduced with the aim to make the scientific articles accessible and visible to all. But a new threat called predatory journals has emerged targeting the young researchers of developing nations. These bogus journals mislead the authors as well as readers in various negative ways. Hence, we should recognize…[Read more]