The findings of the present study might open new avenues to target human disease-causing deadly microbes and viruses.RNA polymerase II (RNA Pol II) plays a major role in gene transcription for eukaryote. One of the major modes of regulation in eukaryotes is the phosphorylation of the carboxyl-terminal domain (CTD) of RNA Pol II. The current study…[Read more]

7%-10.9% to 1.1%-2.6%, Max. bending deflection decreased from 1.3-3.4 mm to 0.4-1.0 mm, and flatness error dropped from 0.9-3.3 mm to 0.3-0.7 mm. The fractographic analysis reveals that the crack initiation is related to alternative V-shape micro-notches at the laser-affected zone; the predominant fracture mechanism involves mode II microvoid…[Read more]

Adult T-cell leukemia (ATL) is an aggressive T-cell lymphoproliferative malignancy of regulatory T lymphocytes (Tregs), caused by human T-cell lymphotropic virus 1 (HTLV-1). Interleukin 2 receptor alpha (IL-2Rα) is expressed in the leukemic cells of smoldering/chronic ATL patients, leading to constitutive activation of the JAK/STAT pathway and…[Read more]

Improvements in anxiety were correlated with an alleviation in respiratory strain. Results imply that hypnosis can contribute to the improvement of anxiety levels and breathing mechanics in severe COPD patients.

ISRCTN10029862.

ISRCTN10029862.

The Global Initiative for Chronic Obstructive Lung Disease 2020 report recommends that…[Read more]

Our findings demonstrate a folded protein system in which spontaneously formed intermolecular disulfide bonds initiate amyloid fibril formation by recruitment of monomers. This dimer-induced aggregation mechanism may be of relevance for human amyloid diseases in which oxidative stress is often an associated hallmark.Land-use intensification can…[Read more]