In addition, treatment of PL caused DNA damage in a dose-dependent manner. PL arrested the cell cycle at S-G2/M phase, and enhanced reactive oxygen species (ROS) generation. Excess ROS generated by PL disrupted mitochondrial membrane resulted in depletion of mitochondrial membrane potential (MMP). These results conclude that PL decreases lung…[Read more]

Plastic marine pollution in the Arctic today illustrates the global distribution of plastic waste of all sizes traveling by wind and waves, entering food chains, and presenting challenges to management and mitigation. While currents move plastics from lower latitudes into the Arctic, significant waste is also generated by remote communities, as…[Read more]

3 years. Majority of them were males (63.8%), had completed bachelor’s degree (53.4%), and were residing in rural Karnataka (77.7%). The knowledge and attitude scores significantly improved (P less then 0.001) post-training, without significant improvement in practical skills. Conclusion It is recommended that future training programs need to be…[Read more]

miRNet is an easy-to-use, web-based platform designed to help elucidate microRNA (miRNA) functions by integrating users’ data with existing knowledge via network-based visual analytics. Since its first release in 2016, miRNet has been accessed by >20 000 researchers worldwide, with ∼100 users on a daily basis. While version 1.0 was focused p…[Read more]

INTRODUCTION In individuals having low back pain, the application of spinal manipulative therapy (SMT) has been shown to reduce spinal stiffness in those who report improvements in post-SMT disability. The underlying mechanism for this rapid change in stiffness is not understood presently. As clinicians and patients may benefit from a better…[Read more]

None of these signals persisted to 18 or 26 years. This study lends further support for a suggestive role of DNAm in the known benefits of breastfeeding on a child’s future health.Conopeptides belonging to the A-superfamily from the venomous molluscs, Conus, are typically α-conotoxins. The α-conotoxins are of interest as therapeutic leads and p…[Read more]

In addition, the carcinogenic aflatoxin B1 was detected in 50% of the cannabis products analyzed (14 samples collected from small retails) at levels exceeding those admitted by the European Union in commodities intended for direct human consumption, thus envisaging the need for effective surveillance of aflatoxin contamination in legal…[Read more]

Modern liver surgeon must be equipped with excellent theoretical and clinical skills to perform a perfect liver resection. A particular and growing relevance is devoted to parenchyma sparing liver surgery (PSS). find more Indeed, reducing the sacrifice of functioning parenchyma is one of the keys of a successful surgery, once oncological issues…[Read more]

The incidence of uterine fibroids, which comprise one of the most common female pelvic tumors, is almost 70-75% for women of reproductive age. With the development of surgical techniques and skills, more individuals prefer minimally invasive methods to treat uterine fibroids. There is no doubt that minimally invasive surgery has broad use for…[Read more]

Neurovascular coupling, the close spatial and temporal relationship between neural activity and hemodynamics, is disrupted in pathological brain states. To understand the altered neurovascular relationship in brain disorders, longitudinal, simultaneous mapping of neural activity and hemodynamics is critical yet challenging to achieve. Here, we use…[Read more]

Results Multivariate logistic regression showed that the DSE, but not DST or DTE, was significantly related to difficult laryngoscopies. Specifically, a DSE ≥ 2.36 cm predicted difficult laryngoscopies with a sensitivity and specificity of 0.818 (95% CI 0.766-0.870) and 0.856 (95% CI 0.809-0.904). Furthermore, when combining the best model c…[Read more]