There were two mild unanticipated adverse events definitely related to the device.

The safety and efficacy of the iTEAR device observed in this study support its indication for treating DED.

Neurostimulation has the potential to improve signs and symptoms of DED.

Neurostimulation has the potential to improve signs and symptoms…[Read more]

Protein degradation is a crucial cellular process in all-living systems. Here, using Mycoplasma pneumoniae as a model organism, we defined the minimal protein degradation machinery required to maintain proteome homeostasis. Then, we conditionally depleted the two essential ATP-dependent proteases. Whereas depletion of Lon results in increased…[Read more]

Tilapia piscidin (TP) 4 is an antimicrobial peptide derived from Nile tilapia (Oreochromis niloticus), which shows broad-spectrum antibacterial activity and excellent cancer-killing ability in vitro and in vivo. Like many other antimicrobial peptides, TP4 treatment causes mitochondrial toxicity in cancer cells. However, the molecular mechanisms…[Read more]