Moreover, the number of migrated and invaded HCC cells was reduced after hsa_circ_0000285 was silenced, while the number of migrated and invaded HCC cells was increased after hsa_circ_0000285 was overexpressed. Moreover, RT-qPCR results revealed that miR-599 was downregulated via overexpression of hsa_circ_0000285, while miR-599 was upregulated…[Read more]

01). Multivariate Cox hazard analysis revealed a significant association between living alone and all-cause death, even after adjusting for other risk factors (hazard ratio 2.30, 95% confidence interval 1.38-3.84, p = 0.001). CONCLUSION Although living alone was not significantly associated with long-term clinical outcomes in patients with ACS…[Read more]

15, 95% CI 1.00-1.31; per 5 μg/m3) than after (OR = 1.04, 95% CI 1.00-1.09; per 5 μg/m3). Children in developed countries showed more severe effects (OR = 1.14, 95% CI 1.02-1.27; per 5 μg/m3). Children who were born to mothers with higher levels of prenatal exposure were at higher risk of asthma and wheezing (OR = 1.07, 95% CI 1.02-1.13; per 5 μg…[Read more]

Artificial intelligence (AI) could improve the efficiency and accuracy of health care delivery, but how will AI influence the patient-clinician relationship? While many suggest that AI might improve the patient-clinician relationship, various underlying assumptions will need to be addressed to bring these potential benefits to fruition. Will…[Read more]

The early detection of high-grade dysplasia in PCLs will provide early surgical treatment and improve outcomes for pancreatic cancer. Despite the high upfront cost of nCLE, the improved diagnostic accuracy and resultant appropriate management have resulted in improved cost effectiveness. Refining the procedure technique and limiting the procedure…[Read more]

LDL cholesterol is by far the best established “causal” cardiovascular risk. It is distributed normally, and the mean value ranges around 100~120 mg/dl. In terms of preventive cardiology, we now know very well that the lower the LDL cholesterol, the better. Clinical usefulness of aggressive LDL-lowering therapies using statin, ezetimibe, and…[Read more]