Parasites of the Plasmodium genus are unable to produce purine nucleotides de novo and depend completely on the salvage pathway. This fact makes plasmodial hypoxanthine-guanine-(xanthine) phosphoribosyltransferase [HG(X)PRT] a valuable target for development of antimalarial agents. A series of nucleotide analogues was designed, synthesized and…[Read more]

After completing the thio-substitution with Lawesson’s reagent, ethanol was found to be effective in the decomposition of the inherent stoichiometric six-membered-ring byproduct from the Lawesson’s reagent to a highly polarized diethyl thiophosphonate. The treatment significantly simplified the following chromatography purification of the desired…[Read more]

Such participant characteristics had greater explanatory power than the experimental manipulations.

Subtle differences in how information is presented may influence critical decisions. However, even among women with the same values, diversity in treatment choice remains.

Subtle differences in how information is presented may influence…[Read more]

In the regression analysis, state anxiety was a predictor of videogame use and addiction (p = 0.01). Further research is needed to confirm these data and to maximize the developmentally positive effects of videogames and preventing the negative consequences.Understanding the potential drivers of microbial meat contamination along the entire meat…[Read more]

Photocatalytic biomass conversion represents an ideal way of generating syngas because of the sustainable use of biomass carbon and solar energy. However, the lack of efficient electron-proton transfer limits its efficiency. We here report an unprecedented method to simultaneously increase both the electron and proton transfer by creating surface…[Read more]

5% of the accessions, with higher frequencies in Europe than in other continents. RMC-7977 The old European wheat variety “Mediterranean” was identified as a putative source of this translocation, suggesting that Yr34 has been used for over 200 years. Finally, we designed diagnostic CAPS and sequenced-based markers that will be useful to…[Read more]

Finally, the challenges and future perspectives for the development of polymeric nanoparticles to combat neurological disorders are discussed.Graphyne (GY) and graphdiyne (GDY) have been employed in photocatalysis since 2012, presenting intriguing electronic and optical properties, such as high electron mobility and intrinsic bandgap due to their…[Read more]

The present study is focused on designing an automated jet nebulizer that possesses the capability of dynamic flow regulation. In the case of existing equipment, 50% of the aerosol is lost to the atmosphere through the vent, during the exhalation phase of respiration. Desired effects of nebulization may not beachieved by neglecting this poor…[Read more]