The SARS-CoV-2 spike employs mobile receptor-binding domains (RBDs) to engage the human ACE2 receptor and to facilitate virus entry, which can occur through low-pH-endosomal pathways. To understand how ACE2 binding and low pH affect spike conformation, we determined cryo-electron microscopy structures-at serological and endosomal pH-delineating…[Read more]

Simulated

At-MABG doses from

I-MIBG using the RAP method were in agreement with those from

At-MABG, so that their boxes overlapped in the box plots. MDM2 inhibitor The RAP method showed applicability to the different cell lines, but it was difficult to predict long-term doses from short-term experimental data.

The present…[Read more]

To explore the application value of lithotomy position in the treatment of tibial shaft fracture with closed reduction and interlocking intramedullary nail fixation.

The clinical data of 78 patients with tibial shaft fractures treated with closed reduction and interlocking intramedullary nail fixation between January 2015 and May 2018 were…[Read more]