Logistic regression analysis for simple nasal bone fracture showed that the relative risk of simple nasal bone fracture is lower in men than in women, and the risk of simple nasal fractures decreased with age increasing. Compared with traffic accident, the relative risk of simple nasal bone fracture is higher in violence injury, sports injury and collision injury. ConclusionThe distribution of the nasal fractures of the inpatients has certain characteristics in terms of individual characteristics, injury cause and fracture types, which is worthy of further strategic study on prevention and treatment of the nasal fractures.ObjectiveTo investigate the perioperative management of endoscopic nasal surgery in patients with cardiovascular disease. MethodSixty-two patients with cardiovascular disease underwent endoscopic sinus surgery. Individualized medical treatment was used according to the patient’s perioperative condition, followed by functional endoscopic surgery. ResultTwo patients had cardiovascular complications after endoscopic surgery and were transferred to internal medicine. One patient developed massive hemorrhage after operation, and hemostasis was performed again under nasal endoscopic surgery. The remaining 59 patients had no adverse cardiovascular events after operation. There are no complications such as massive hemorrhage, visual impairment, and cerebrospinal fluid rhinorrhea. All patients were followed up for more than half a year, 39 cases（62.90%） of nasal sinus disease were completely controlled, 18 cases（29.03%） of nasal sinus disease were partially controlled, and the effective rate was 91.94%. ConclusionReasonable perioperative management measures can reduce the risk of nasal sinus surgery in patients with cardiovascular disease, ensure the successfully implementation of surgery and achieve a successful prognosis.ObjectiveTo observe the effect of sublingual immunotherapy on the expression of serum inflammatory factors IL-4 and TNF-α as well as autophagy-associated protein LC3 in nasal mucosa in patients with allergic rhinitis（AR）. MethodForty patients with AR were randomly divided into SLIT group（n=20） and control group（n=20）, the SLIT group received a 2-year intervention with a standardized dust mite vaccine SLIT in combination with conventional drugs, the control group received placebo and conventional drug treatment. Blood samples and inferior turbinate mucosa were collected of both groups before and after the treatment; the clinical symptoms, signs and medication scores of the two groups before and after treatment were analyzed; the expressions of serum IL-4 and TNF-α were detected by ELISA before and after treatment; the expression of autophagy-related protein LC3 was detected by Western blot. ResultThere were no significant differences in the pre-treatment signs, symptoms, medication scores, age, gender, serum IL-4, TNF-α, and LC3 expression between the SLIT group and the control group（P>0.05）. After a 2-year treatment, the symptom scores the of SLIT group were significantly improved compared with the control group; serum levels of IL-4 and TNF-α were significantly decreased in the SLIT group; the expression of autophagy-related protein LC3 in the SLIT group was significantly lower than that in the control group, and the difference was statistically significant（P less then 0.05）. ConclusionSLIT combined with conventional drug therapy is more effective in improving the symptoms of AR patients than conventional drug therapy. SLIT can reduce the inflammation level and expression of autophagy-related proteins in AR patients to a certain extent.ObjectiveTo investigate the current situation of hearing and the changing trend of hearing loss in all age groups in Hunan Province, and to explore the incidence of age-related hearing impairment and the feasibility of early screening in aging people. E64d MethodA total of 13 681 subjects were divided into different age groups of 31-40 years old, 41-50 years old, 51-60 years old, 61-70 years old, 71-80 years old, and >80 years old. The average value of speech frequency hearing threshold （0.5, 1.0 and 2.0 kHz frequency） was calculated as an average hearing threshold. 4.0 and 8.0 kHz were high frequency sounds, hearing threshold > 25 dB at 4.0 and 8.0 kHz is the high-frequency pure-tone hearing loss. ResultThe proportion of hearing loss was the lowest in the 31-40 years old group （6.8%）, whereas the proportion of hearing loss was the highest in the >80-year-old group （91.6%）. The proportion and degree of hearing loss increased with the increase of age （P60 years old group than that of the 31-60 years old group, and the difference was statistically significant （P less then 0.05）. ConclusionThe proportion and degree of hearing loss in adult populations in Hunan Province significantly increased with age; hearing loss show up in the early age of the elderly; people with normal speech frequency hearing threshold should also routinely perform the high-frequency hearing test; speech frequency and high-frequency pure-tone hearing testing could be used in early detection of pre-sensual hearing loss, and its extent of routine hearing impairment screening will facilitate early intervention.ObjectiveTo investigate the clinical characteristics and prognostic factors of adult rhabdomyosarcoma（RMS） of nasal cavity and sinus. MethodThere were 35 adult patients with RMS, including 22 with embryonal type and 13 with acinar type. Surgery + chemoradiotherapy（17 cases）, surgery + radiotherapy（6 cases）, surgery + chemotherapy（7 cases）（4 cases of seed implantation after surgery and chemotherapy）; Five patients were treated with antitumor drugs instead of surgery. ResultThe study follow-up 9-62 months, adult nasal sinuses RMS total 5 years survival rate was 2.9%, among them the IRS stage>Ⅱ period, the infiltration of the skull base tumor, local lymph node metastasis, tumor diameter of 5 cm or more, 50% or higher Ki-67 are poor prognosis factor. ConclusionRMS in nasal cavity and sinus are mostly embryonal type in adults, and the 5-year overall survival rate is low, which is related to larger primary tumor volume, local lymph node metastasis, skull base infiltration and higher ki-67 ratio at the first diagnosis in adults.