BET degraders potently induced apoptosis in sensitive NSCLC cells and were accompanied by reduction of Mcl-1 and c-FLIP levels, which are critical for mediating induction of apoptosis and enhancement of TRAIL-induced apoptosis. Accordingly, ZBC260 exerted more potent activity than JQ-1 in vivo against the growth of NSCLC xenografts and…[Read more]

the intraperitoneal and combined site recurrence groups. (OS – 93.07, 47.9 and 41.7 months, respectively, p  less then  .001, PRS – 68.57, 29.67 and 19.7 months, respectively, p  less then  .001). On cox’s regression analysis, retroperitoneal recurrence was found to be an independent prognostic factor for survival. CONCLUSIONS The site of recurren…[Read more]

Our results would provide insights into the molecular mechanisms of scale degeneration in G. eckloni and other congeneric fishes. In addition, the transcriptome data provides candidate genes and markers for future studies.

Our results would provide insights into the molecular mechanisms of scale degeneration in G. eckloni and other congeneric…[Read more]