Mechanistically, GABPB1-AS1 acted as a competing endogenous RNA (ceRNA) by sponging miR-519e-5p, resulting in the de-repression of its target gene Notch2 which is well known as an oncogene. Therefore, GABPB1-AS1 functioned as a tumor activator in CC pathogenesis by binding to miR-519e-5p and destroying its tumor suppressive function. Collectively,…[Read more]

Our results reveal modest isoform preferences for individual client phospholigands and demonstrate that FC differentially stabilizes PPIs involving 14-3-3σ. Together, these data support the feasibility of developing FC variants with enhanced isoform selectivity.

Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) is a rare, late-onset…[Read more]

An effect of skeletal classification on OPA and a sex effect on NPA were observed. The annual change in the mean of TPA volume decreased in subjects aged 10-12years, then rebounded until 14years. TPA change peaked in female subjects 1year before male subjects.

An effect of skeletal classification on OPA and a sex effect on NPA were observed.…[Read more]

In this review we (i) highlight the large number of species and biotypes which are yet to be described and explore their applicability, (ii) present how it is possible to take advantage of the mirid-induced plant defenses to improve pest management, (iii) argue that genetic selection of improved mirid strains is feasible, (iv) explore the use of…[Read more]

13%), alcohol use (40% vs. 22%), fighting (13% vs. 5%), suicidal ideation (31% vs. 13%), and suicide attempts (17% vs. 5%), as well as lower school engagement, educational aspirations, and grades than 19,832 students who dated without TDA. The current study emphasized the need for dating aggression to be a focus of secondary school prevention…[Read more]

Although assessing nutrient intake through dietary surveys is desirable, it can be effort- and time-intensive. We aimed to develop a brief screening method for determining sodium intake in order to raise public awareness regarding the Dietary Reference Intakes for Japanese (DRI-J) 2020.

Using data from the 2015 National Health and…[Read more]

004) was detected. Subjects with repeated hospitalizations were more often committed to psychiatric residential facilities at discharge (p=0.002). Treatment features related to RDH were represented by a higher prescription rate of atypical antipsychotics (p=0.030), benzodiazepines (p=0.001) and antidepressants (p=0.048).

Findings from the…[Read more]