Inactivation of genes within the arn operon led to increased susceptibility of P. aeruginosa to AZM and great increases in synergy between AZM and other antimicrobial agents, indicating that dysregulation of the arn operon might explain increased AZM uptake and synergy in host-like media. Furthermore, genes involved in central and energy…[Read more]

Under this condition, we substituted sorafenib of 400 mg/d for lenvatinib of 10 mg/d. After a 5-mo prescription, not only hypertension and peripheral edema were greatly improved, but also proteinuria was improved from grade three to grade one (estimated 24-h urine protein 962 mg). At the same time the cancer control was achieved, judged from…[Read more]

Myocardial ischemia/reperfusion (I/R) injury is a common cause of mortality. Cardiac miR-146a is emerging as a potent regulator of myocardial function. Dexmedetomidine preconditioning provides cardioprotective effects, of which mechanisms related to miR-146a-3p are unclear.

A myocardial I/R model in rats and a cellular anoxia/reoxygenation…[Read more]

The problematic consumption of legal and illegal substances in pregnant and postpartum women is a growing socio-sanitary concern that has infrequently been studied from a gender perspective. This article presents the results of a multi-center, cross sectional study employing a mixed qualitative-quantitative approach that was conducted between May…[Read more]