Organic nitrates (R-ONO2; R, organic residue) such as nitroglycerin are used as drugs in part for more than a century. Their pharmacological use is associated with clinically relevant tolerance which is reportedly known since 1888. The underlying mechanisms of both, the mechanisms of action and the main pharmacological effect, which is…[Read more]

Organic nitrates (R-ONO2; R, organic residue) such as nitroglycerin are used as drugs in part for more than a century. Their pharmacological use is associated with clinically relevant tolerance which is reportedly known since 1888. The underlying mechanisms of both, the mechanisms of action and the main pharmacological effect, which is…[Read more]

90 ± 0.59%; 8.05 ± 0.72% P =  < .001), (7.52 ± 0.31%; 7.00 ± 0.59% P =  < .001), (7.25 ± 0.31%; 6.90 ± 0.73% P = .006), respectively].

Diabetes may have cataractous effect in anterior, nuclear and posterior regions of the lens.

Diabetes may have cataractous effect in anterior, nuclear and posterior regions of the lens.

The aim of…[Read more]

have acceptable predictive value for persistent/recurrent papillary thyroid cancer patients.

The revised American Thyroid Association initial and response-to-therapy risk stratifications have acceptable predictive value for persistent/recurrent papillary thyroid cancer patients.

The opioid epidemic has reached a crisis level in America, and…[Read more]

In addition, in the model of delayed GE induced by loperamide and cisplatin, C. aurantium L. administration reversed the GE deficit. Furthermore, C. aurantium L. significantly reduced gastric cancer proliferation. Conclusion The results indicate that C. aurantium L. could become a new drug for gastrointestinal prokinetic and gastric cancer…[Read more]

These measures resulted in a rapid response and disease control.

Acute myeloid leukemia with the NUP98/RARG fusion gene and the RUNX1 mutation may be a special subtype of AML and may benefit from the alkaloid-based regimen.

Acute myeloid leukemia with the NUP98/RARG fusion gene and the RUNX1 mutation may be a special subtype of AML and…[Read more]

CONTEXT Immune checkpoint inhibitors (ICIs), as anti-programmed cell death protein-1 (PD-1), anti-programmed cell death protein-ligand 1 (PD-L1), and anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) monoclonal antibodies, are approved for the treatment of some types of advanced cancer. Their main treatment-related side-effects are immune-related…[Read more]

BACKGROUND Esophageal carcinoma is a malignant gastrointestinal tumor with a very poor prognosis. MicroRNA (miR)-1304 is a newly discovered non-coding RNA, which shows differential expression in other cancers, and its clinical value in esophageal carcinoma remains unclear. AIM To explore the expression of miR-1304 in patients with esophageal…[Read more]

05 ppmv or 0.1 ppmv of ClO2 gas just as on the control cells. Also in the investigation for cell death, 0.05 ppmv and 0.1 ppmv of ClO2 gas little affected the viability, apoptosis or necrosis of MSCs. read more Furthermore, we assessed senescence using SA-β-gal staining. Although the frequency of stained cells cultured in 0.1 ppmv of ClO2 gas was…[Read more]

h insurance and/or having access to healthcare. Younger age groups and men are the most vulnerable. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.OBJECTIVE Here we looked for possible mechanisms regulating the progression of type 1 diabetes mellitus (T1DM). In this disease, autoaggressive T cells (T…[Read more]

ITMC typically presents as a cystic lesion with a complete capsule that can be treated successfully via an endoscopic tympanotomy approach, but in a minority of cases a more extensive mastoidectomy may be required.

Intact tympanic membrane cholesteatoma in adults may have both congenital and acquired origins, but it is not possible to…[Read more]