clinical application, TRF2 is expected to become a new type of cancer prognostic marker and a new tumor treatment target. Inhibition of TRF2 overexpression could effectively cut off the core network regulating tumor cell survival, reduce drug resistance, or bypass the mutation under the pressure of tumor treatment selection, which may represent a…[Read more]

In this work, three benzodithiophene-benzotriazole alternated wide band gap copolymers attaching symmetric or asymmetric conjugated side chains, namely, PDBTFBTA-2T, PBDTFTBA-TSi, and PBDTFBTA-2Si, were developed for efficient nonfullerene polymer solar cells. The symmetry effect of the side chains was investigated in detail on the overall…[Read more]

Immune-mediated destruction of insulin-producing β cells causes type 1 diabetes (T1D). However, how β cells participate in their own destruction during the disease process is poorly understood. selleckchem Here, we report that modulating the unfolded protein response (UPR) in β cells of non-obese diabetic (NOD) mice by deleting the UPR sensor IR…[Read more]

in English, Portuguese, O objetivo do estudo aqui apresentado foi analisar a cobertura da grande imprensa nacional sobre o aborto em caso de Zika e examinar se esta reforçou os discursos já associados à prática ou se ampliou e qualificou a discussão sobre o tema. Trata-se de pesquisa qualitativa realizada com base na análise de 43 notícias sobre…[Read more]

Herein, a thin film nanocomposite (TFN) membrane was prepared through deposition of a very thin mixed matrix layer of PEBAX®1657/chitosan-wrapped multiwalled carbon nanotubes (CWNTs) on an ultraporous polyethersulfone (PES) substrate. The eco-friendly CWNTs were synthesized via non-covalent functionalization of MWNTs by carbohydrate polymer…[Read more]

PURPOSE Psychological stress and ensuing modulation of the immune and nervous systems can have a significant impact on itch. Stress can exacerbate itch and vice versa, resulting in a vicious cycle that can greatly impair a patient’s quality of life. This review summarizes the association between stress and itch, elucidates the mechanism by which…[Read more]

On the other hand, C. erythropterus has the highest Hg concentration due to its relatively high trophic level position. The average THQ value of metals in fish tissue decrease in the order of As > Hg > Pb > Cd > Cr and the total THQ of average metal concentration in fish species decreased in the order of C. auratus > C. erythropterus > H.…[Read more]

The results from both tasks indicate that people anticipate their future motor performance so as to make decisions that will improve their expected future reward.The relationship between plant traits and species relative abundance along environmental gradients can provide important insights on the determinants of community structure. Here we bring…[Read more]