We reported that the absence of a guanine oxidized (GO) system or the AP-endonucleases Nfo, ExoA and Nth promoted stress-associated mutagenesis (SAM) in B. learn more subtilis YB955 (hisC952, metB5, leuc427). Moreover, MutY-promoted SAM was Mfd-dependent suggesting that transcriptional transactions over non-bulky DNA lesions promoted error-prone…[Read more]

Patients with severe or refractory disease were treated with autologous bone marrow transplantation, melphalan, or bortezomib with dexamethasone. CONCLUSIONS AND RELEVANCE Consideration of patient comorbidities, disease distribution, clinician experience, and treatment accessibility is mandatory in every therapeutic approach of scleromyxedema. ©…[Read more]

The condition of some patients with COVID-19 progress rapidly and require aggressive treatments and intensive care, such as endotracheal intubation.•Emergency endotracheal intubation in critically ill patients with COVID-19 has posed a huge challenge to the self-protection of anesthesiologists.•Anesthesiologists from the frontline of Wuhan, Chi…[Read more]

yotic acidocalcisomes should have similar features. Since hardly any information is available on bacterial acidocalcisomes this study aimed at the characterization of organelle-like structures in α-proteobacterial cells at the example of A. tumefaciens. Copyright © 2020 American Society for Microbiology.There is a growing need for a highly s…[Read more]