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James Spence posted an update 5 hours, 29 minutes ago
dicate a shift in balance towards type I collagen synthesis in HFmrEF compared with HFpEF.
Several clinical trials have addressed the therapeutic strategy of adding dipeptidyl peptidase 4 (DPP-4) inhibitors to the treatment of type 2 diabetes mellitus (DM) inadequately controlled by insulin therapy. However, there is a high degree of…[Read more]
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James Spence posted an update 2 days, 5 hours ago
The composition of a sample solvent has a crucial impact on separations in hydrophilic interaction liquid chromatography (HILIC). In this short communication, we studied the effect of an organic modifier in the sample solvent on the solubility of different tryptic glycopeptides of hemopexin and haptoglobin proteins. The results showed that the…[Read more]
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James Spence posted an update 3 days, 5 hours ago
The detector was composed of a 12 × 12 lutetium fine silicate (LFS) array coupled with a 12 × 12 multi-pixel photon counter (MPPC) array. Each LFS crystal with a size of 4.14 × 4.14 × 10 mm3was individually coupled to a separate MPPC. Singles list-mode data from each detector were stored, and coincidences were identified using a coi…[Read more]
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James Spence posted an update 4 days, 5 hours ago
Drug discovery campaigns are hampered by substantial attrition rates largely due to a lack of efficacy and safety reasons associated with candidate drugs. This is true in particular for genetically complex diseases, where insufficient knowledge of the modulatory actions of candidate drugs on targets and entire target pathways further adds to the…[Read more]
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James Spence posted an update 5 days, 5 hours ago
To investigate the efficacy of Huangqin Qingre Chubi Capsules(HQC) in patients with ankylosing spondylitis(AS) and its effect on oxidative stress, and to explore its possible mechanism. Fifty-eight cases of AS patients were randomly divided into HQC group and salazosulfapyridine(SASP) group. Another 30 healthy people were employed as a control…[Read more]
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James Spence posted an update 5 days, 16 hours ago
PreCOT was negatively correlated with lactation number only in multiparous cows (n = 41, ρ = -0.50, P less then .01). This study implied that OC differentiation toward calving was tapered in cows with advanced parities, and these indexes predict the risk of MF.Objective The aim of this study is to determine the prevalence of severe acute…[Read more]
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