Dupilumab has been demonstrated to be an effective treatment for patients with moderate-to-severe atopic dermatitis (AD) in clinical trials. However, evidence of real-world experience with dupilumab in a broader population is limited to date.

Adult patients with moderate-to-severe AD, defined as an Eczema Area Severity Index (EASI) score…[Read more]

The CDS is a self-report instrument with initial evidence for its validity and reliability. It is a promising tool to identify the triggers of disgust in colostomy contexts, which can be of great importance for promoting the mental health of colostomy patients.Podocytes are highly specialized cells that play an essential role in maintaining the…[Read more]

Under CB-5083 treatment, HAE6 is also strongly membrane-associated, suggesting ER localization. Finally, we provide an experimental example where CB-5083 treatment offers clarity to the off-target effects of MG132 treatment.A new cytorhabdovirus was identified in zucchini (Cucurbita pepo) in Greece with the aid of high-throughput sequencing…[Read more]

In addition, the respective life cycle inventories (LCIs) are provided, enabling the identification of resource hot spots and quantifying the environmental benefits of end-of-life options.Heightened levels of carbon dioxide (CO2) and other greenhouse gases (GHGs) have prompted research into techniques for their capture and separation, including…[Read more]

OBJECTIVES To report surgical technique, intra- and post-operative complications, and short- and long-term outcome following canine hepatobiliary surgery in which exposure of intra-abdominal hepatobiliary lesions was aided by diaphragmotomy. MATERIALS AND METHODS Clinical records from four multi-disciplinary UK-based small animal referral…[Read more]

OBJECTIVES To report surgical technique, intra- and post-operative complications, and short- and long-term outcome following canine hepatobiliary surgery in which exposure of intra-abdominal hepatobiliary lesions was aided by diaphragmotomy. MATERIALS AND METHODS Clinical records from four multi-disciplinary UK-based small animal referral…[Read more]

Spectrometric analysis is one of the most widely used approaches to characterize the chemical nature of microplastics. Despite recent developments, this key step remains time consuming. The aim of this paper is to propose a new method for the pre-detection of microplastics based on mid-infrared imaging. Plastic particles were mixed with sand…[Read more]

The most abundant fatty acids identified were C160, C161, C180, and C183. Obtained lipid profiles allowed to distinguish the tested bacterial strains.

To assess the relationship between knowledge, family attitudes of Tuberculosis patients and prevention efforts for tuberculosis.

The type of research carried out is quantitative by using…[Read more]

Remdesivir has reported efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and in vivo Drug-drug interactions limit therapeutic options in transplant patients. Remdesivir and its metabolite GS-441524 are excreted principally in urine. In intensive care unit (ICU) settings, in which multiple-organ dysfunctions…[Read more]

The purpose of the present work was to investigate the effect doping with lanthanum aluminate on the phase assemblage and thermal behavior of zirconia ceramics for biomedical applications. Four compositions were prepared by a surface modification route of either conventional tetragonal zirconia (3Y-TZP) or high translucency cubic-based zirconia…[Read more]

The spatial distribution of each disease varied across west Adelaide. Spatial convergence of the three diseases was observed in two large hot spot clusters and one main cluster of cold spots.

Due to underreporting, potentially significant covariates like alcohol intake were unable to be assessed. There may be a bias towards…[Read more]

Alzheimer’s disease is a progressive neurodegenerative disorder, with the strongest disease-associated changes observed at clinical or end-stage disease. Transcriptomic deregulation of miRNA expression can spread via “horizontal” RNA transfer through extracellular vesicles (EVs) to act in conjunction with proteins, leading to changes in mRNA,…[Read more]