05). Furthermore, fullerene supplementation decreased serum concentrations of inflammatory cytokine and lipopolysaccharide (LPS; a penetrability marker) compared to the DON-challenged group (p less then 0.05). The current study suggests that fullerene C60 improves intestinal antioxidant status against DON-induced oxidative stress in vitro and in vivo.In this study, Fe3O4-ZrO2 functionalized with 3-aminopropyltriethoxysilane (Fe3O4-ZrO2@APS) nanocomposite was investigated as a nanoadsorbent for the removal of Cd(II), Cu(II), Mn (II) and Ni(II) ions from aqueous solution and real samples in batch mode systems. The prepared magnetic nanomaterials were characterized using X-ray powder diffraction (XRD), scanning electron microscopy/energy dispersion x-ray (SEM/EDX) Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM). Factors (such as adsorbent dose and sample pH) affecting the adsorption behavior of the removal process were studied using the response surface methodology. Under optimized condition, equilibrium data obtained were fitted into the Langmuir and Freundlich isotherms and the data fitted well with Langmuir isotherms. Langmuir adsorption capacities (mg/g) were found to be 113, 111, 128, and 123 mg/g for Cd, Cu, Ni and Mn, respectively. In addition, the adsorption kinetics was analyzed using five kinetic models, pseudo-first order, pseudo-second order, intraparticle diffusion and Boyd models. The adsorbent was successfully applied for removal of Cd(II), Cu(II), Mn (II) and Ni(II) ions in wastewater samples.Many colon cancer patients show resistance to their treatments. Therefore, it is important to consider unique characteristic of each tumor to find the best treatment options for each patient. In this study, we develop a data driven mathematical model for interaction between the tumor microenvironment and FOLFIRI drug agents in colon cancer. Patients are divided into five distinct clusters based on their estimated immune cell fractions obtained from their primary tumors’ gene expression data. We then analyze the effects of drugs on cancer cells and immune cells in each group, and we observe different responses to the FOLFIRI drugs between patients in different immune groups. For instance, patients in cluster 3 with the highest T-reg/T-helper ratio respond better to the FOLFIRI treatment, while patients in cluster 2 with the lowest T-reg/T-helper ratio resist the treatment. Moreover, we use ROC curve to validate the model using the tumor status of the patients at their follow up, and the model predicts well for the earlier follow up days.Hormone receptor expression patterns often correlate with infiltration of specific lymphocytes in tumors. Specifically, the presence of specific tumor-infiltrating lymphocytes (TILs) with particular hormone receptor expression is reportedly associated with breast cancer, however, this has not been revealed in epithelial ovarian cancer (EOC). Therefore, we investigated the association between hormone receptor expression and TILs in EOC. Here we found that ERα, AR, and GR expression increased in EOC, while PR was significantly reduced and ERβ expression showed a reduced trend compared to normal epithelium. Cluster analysis indicated poor disease-free survival (DFS) in AR+/GR+/PR+ subgroup (triple dominant group); while the Cox proportional-hazards model highlighted the triple dominant group as an independent prognostic factor for DFS. In addition, significant upregulation of FoxP3+ TILs, PD-1, and PD-L1 was observed in the triple dominant group compared to other groups. Paclitaxel datasheet NanoString analyses further suggested that tumor necrosis factor (TNF) and/or NF-κB signaling pathways were activated with significant upregulation of RELA, MAP3K5, TNFAIP3, BCL2L1, RIPK1, TRAF2, PARP1, and AKT1 in the triple dominant EOC group. The triple dominant subgroup correlates with poor prognosis in EOC. Moreover, the TNF and/or NF-κB signaling pathways may be responsible for hormone-mediated inhibition of the immune microenvironment.Though chemically-derived reduced graphene oxide (CDG) from graphite oxide (GO) precursors is a widely practiced procedure for the large-scale production of graphene, the quality and quantity of thus obtained CDG is dependent on the reduction strategy used. In this work, we report an all-solid-state, residue-free, microwave process for the reduction of graphene oxide and subsequent growth of carbon nanotube ‘separators’ from a single precursor, namely DABCO (1,4-diazabicyclo[2.2.2]octane). The utility of our newly developed technique in efficiently and effectively reducing graphene oxide and in growing nitrogen-doped carbon nanotubes via catalysts like palladium and iron into unique mesoporous, 3-D hierarchical carbon nanostructures is demonstrated. The applicability of the thus obtained palladium embedded in Pd@NCNT-rGO nanoarchitectures for the oxygen reduction reaction (ORR) is investigated. When carbon fiber (CF) was used as the substrate, three-dimensional Fe@NCNT-CF were obtained, whose capability as versatile adsorbents for hexavalent chromium ion removal from contaminated waters was also demonstrated.Since most plant movements take place through an interplay of elastic deformation and strengthening tissues, they are thus ideal concept generators for biomimetic hingeless actuators. In the framework of a biomimetic biology push process, we present the transfer of the functional movement principles of hollow tubular geometries that are surrounded by a net-like structure. Our plant models are the recent genera Ochroma (balsa) and Carica (papaya) as well as the fossil seed fern Lyginopteris oldhamia, which hold a net of macroscopic fiber structures enveloping the whole trunk. Asymmetries in these fiber nets, which are specifically caused by asymmetric growth of the secondary wood, enable the up-righting of inclined Ochroma and Carica stems. In a tubular net-like structure, the fiber angles play a crucial role in stress-strain relationships. When braided tubes are subjected to internal pressure, they become shorter and thicker if the fiber angle is greater than 54.7°. However, if the fiber angle is less than 54.