When cognitive decline is observed in cancer patients, it is necessary to actively evaluate the serum levels of some B vitamins, including VB12.

When cognitive decline is observed in cancer patients, it is necessary to actively evaluate the serum levels of some B vitamins, including VB12.

Fatigue is having high prevalence and increased…[Read more]

In addition, we have determined the crystal structures of this enzyme and its complex with YM155, revealing a unique binding mode. YM155 simultaneously targets three “hot” spots on PLpro, including the substrate-binding pocket, the interferon stimulating gene product 15 (ISG15) binding site and zinc finger motif. Our results demonstrate the…[Read more]

According to the MEPS criteria, the outcomes were excellent in five cases, good in two cases, fair in one case, and poor in three cases. Four patients were delayed cases, who underwent surgery two weeks after injury. The average operation time was significantly longer in four children sustaining delayed surgery (140 ± 43 min, vs. 50 ± 12 min, p &…[Read more]

We propose an algorithm, based on the available evidence and current guidelines, to guide the use of DOACs based on severity of obesity. Any DOAC can be used in obese patients with a BMI less than 40kg/m2. In patients with a BMI of 40-50 kg/m2, warfarin should be used, but apixaban or edoxaban can be considered.. In obese patients with a BMI…[Read more]

Common buckwheat (Fagopyrum esculentum Moench), a dicotyledonous plant in family Polygonaceae, is recognized as a valuable nutritional source of fatty acids, phytosterols, phenolic compounds and tocopherols. It has received increased attention as a so-called “functional food” in China. During scouting of common buckwheat in August and September…[Read more]