Interfacial inhibitors exert their biological effects through co-association with two macromolecules. The pateamine A (PatA) class of molecules function by stabilizing eukaryotic initiation factor (eIF) 4A RNA helicase onto RNA, resulting in translation initiation inhibition. Here, we present the crystal structure of an eIF4A1RNA complex bound to…[Read more]

stratification and pathobiology.

Plasma prolargin levels differentiate PAH patients from controls and the other investigated dyspnoea groups including HF. Its potential in PAH differentiation may be enhanced by inclusion in a multi-marker panel. Larger studies are needed to evaluate its discriminative ability of PAH in relation to other…[Read more]

This eliminates the burden of solving the optimization problem for many values of the Lagrange multiplier. That is, we prove that we can solve the original constrained problem with a single optimization.The fundamental information theory functions of entropy, relative entropy, and mutual information are directly applicable to clinical diagnostic…[Read more]

Finally, we demonstrate that local infusion of DCS or AICP into the GPe improved motor function in a mouse model of PD. Together, these results demonstrate that GluN2C-containing receptors and potentially GluN2D-containing receptors in the GPe may serve as a therapeutic target for alleviating motor dysfunction in PD and related disorders.In…[Read more]