All the results suggest that the indoline derivatives may be a class of novel tubulin inhibitors with potential anticancer activity, and which is worthy of further study.Harnessing the potential of biocatalytic conversion of renewable biomass into value-added products is still hampered by unfavorable process economics. This has promoted the use of…[Read more]

Importantly, SYD985 was effective in these models, showing that the resistance to first generation ADCs can be overcome with an improved design.Recently, the identification and detection of children with autism spectrum disorder (ASD) has become an essential issue under ASD intervention services. The high percentage of ASD among children requires…[Read more]

The SLTB 2019 scientific meeting was held on 2-4th October, in the historic Antigua de Fabrica Tobacos building of the Universidad of Seville and was hosted by Professor Ramon Risco and Dr Ariadna Corral. The meeting included a workshop on cryopreservation of cell therapy products (2nd October 2019) run in collaboration with the UK’s Stem Cells…[Read more]

Gastric cancer (GC) is a prevalent malignancy worldwide; the Epstein-Barr Virus (EBV) also affects many people worldwide. An important association has been seen in these two diseases that could explain causality and a possible viral etiology of GC as has been seen with Helicobacter pylori. This study aims to identify genes expressed in malignant…[Read more]

The impact of disease-modifying agents on disease progression in Parkinson’s disease is largely assessed in clinical trials using clinical rating scales. These scales have drawbacks in terms of their ability to capture the fluctuating nature of symptoms while living in a naturalistic environment. The SPHERE (Sensor Platform for HEalthcare in a…[Read more]

Neurons in primate V4 exhibit various types of selectivity for contour shapes, including curves, angles, and simple shapes. How are these neurons organized in V4 remains unclear. Using intrinsic signal optical imaging and two-photon calcium imaging, we observed submillimeter functional domains in V4 that contained neurons preferring curved…[Read more]

uration of surgery compares favorably with conventional combined hilar approaches.The COVID-19 pandemic swept the globe in January of 2020 causing mass panic and extreme hysteria. While pandemics are not new, COVID-19 is emerging as a public health crisis in nearly every household in America. In this paper, I discuss how COVID-19 has ravaged one…[Read more]