Slit guidance ligands (Slits) and their roundabout (Robo) family of receptors are well-known axon guidance molecules that were originally identified in Drosophila mutants with commissural axon pathfinding defects. Shikonin clinical trial However, Slit-Robo signaling has been shown to be involved in not only neurogenesis, but also the development…[Read more]

In all patients, nasal pain was accompanied by ictal semiological features, such as autonomic, olfactory, abdominal, or psychic auras, and focal impaired awareness seizures, which are typically associated with mesial temporal lobe epilepsy.

Our findings suggest that nasal pain can occur as an epileptic aura in patients with temporal lobe…[Read more]

In response to concerns about patient care and safety, our urban, tertiary care, Level 1 trauma center adult emergency department (ED) created an advanced practice provider-staffed critical care step-down unit (CCSU). We conducted a comprehensive evaluation of the CCSU’s impact on patient care, safety, and ED operations.

We compared ED…[Read more]

o the PV group. This trial has been registered at clinicaltrials.gov (NCT03946085).Discovery and identification of novel insecticidal proteins in Bacillus thuringiensis (Bt) strains are of crucial importance for efficient biological control of pests and better management of insect resistance. In this study, the Bt strain KhF, toxic for Plodia…[Read more]

Freezing of gait (FOG) is a major hindrance to daily mobility and can lead to falling in people with Parkinson’s disease. While wearable accelerometers and gyroscopes have been commonly used for FOG detection, foot plantar pressure distribution could also be considered for this application, given its usefulness in previous gait-based…[Read more]

OHASIS data revealed subgroups that seemed to be well protected, while pointing to exposure situations that beckoned policy development, as well as identified subgroups of workers for whom better training is warranted. CONCLUSIONS Functional occupational health surveillance systems can identify subgroups most at risk as well as areas of programme…[Read more]

Two bacterial strains, 172606-1T and BT10T, were isolated from soil, Korea. Both strains were Gram-stain-negative and rod-shaped bacteria. Phylogenetic analyses based on 16S rRNA gene sequences showed that strain 172606-1T formed a distinct lineage within the family Cytophagaceae (order Cytophagales, class Cytophagia, phylum Bacteroidetes). Asunapr…[Read more]

Poststroke depression (PSD) negatively affects the functional outcome of stroke patients. Patient Health Questionnaire-9 (PHQ-9) is a validated screening tool for detecting PSD. This study investigated the relationship between PHQ-9 score and functional outcomes in stroke patients in a convalescent rehabilitation ward by evaluating functional…[Read more]

Virtual surgery system can provide us a realistic and immersive training environment, in which haptic force-feedback gives operators ‘touching feeling.’ Appropriate deformation models of soft and hard tissues are required for the achievement of real-time haptic feedback. To improve accuracy of modeling and haptic feedback simulation for…[Read more]