Zika virus (ZIKV) infection in both infants and adults is associated with neurological complications including, but not limited to, microcephaly and Guillain-Barre syndrome. Antibody therapy can be effective against virus infection. We isolated ZIKV envelope domain III-specific neutralizing antibodies (nAbs) from two convalescent patients with…[Read more]

Due to the large volume of pipeline transportation, low cost, safety and the reliability, and automatic control, it is widely used in many fields of industrial development and human daily life. Most of the traditional hydraulic pipelines are steel pipes, and their structure is simple. High resistance and high consumption during transportation are…[Read more]

The treatment options include interferon-alpha, anakinra, and immunosuppressive therapies. Better understanding of disease pathogenesis has led to development of novel targeted and effective therapies including BRAF and MEK inhibitors. The rarity of the disease and variable clinical features and course often results in diagnostic errors and…[Read more]

In summary, the safety and efficacy of various antiviral drugs need to be confirmed by large samples and high-quality RCT studies.

The registration system of clinical trials and the level of clinical trial design need to be further improved. At present, no specific drug has been found for the treatment of COVID-19, the efficacy of antiviral…[Read more]

This study demonstrated that NGS can accurately detect BRCA1 gLGRs in primary tumors, suggesting that gLGR evaluation in BRCA1 locus should be performed in cases when the screening for BRCA alterations starts from tumor instead of blood. NGS sequencing of tumor samples may become the preferred method to detect both somatic and germline gLGRs in…[Read more]

Vortioxetine is approved for the treatment of Major Depressive Disorder (MDD). However, the safety of this drug in a large group of populations is still unclear. Thus, we have tried to analyze the risk profile of vortioxetine.

The data related to the risk profile of vortioxetine has been extracted from Pub-Med from January 2014 to May…[Read more]

5 h retained (R)-7a with over 99% ees and 43.2% yields. Furthermore, the sources of high regiocomplementarity of GmEH3 for (S)- and (R)-5a as well as high enantioselectivity towards rac-7a were analyzed via molecular docking (MD) simulation.To explore an effective enzyme combination instead of a common enzyme method, sequential α-amylase and…[Read more]