To examine 5-year prospective associations between working conditions and work ability among employees in Germany.

A cohort study (2011/2012-2017), based on a random sample of employees in employments subject to payment of social contributions aged 31-60years (Study on Mental Health at Work; S-MGA; N = 2,078), included data on physical and…[Read more]

Furthermore, the peptidomimetic enhancer exhibited only a marginal effect on the viability of mammalian HepG2 cells even at concentrations 100-fold higher than that enabling the antibiotic enhancement. Also, a low hemolytic activity combined with limited in vivo acute toxicity of CEP-136 in healthy mice allowed in vivo validation of the…[Read more]

Cooperative binding is a key feature of metabolic pathways, signaling, and transport processes. It provides tight regulation over a narrow concentration interval of a ligand, thus enabling switching to be triggered by small concentration variations. The data presented in this work reveal strong positive cooperativity of α-synuclein binding to…[Read more]

Airway obstruction is the second leading cause of potentially preventable death on the battlefield. Endotracheal intubation is a critical skill needed by emergency military physicians to manage these patients. Our objective is to describe the development of the Defense Registry for Emergency Airway Management (DREAM) at Brooke Army Medical Center…[Read more]

8 months, P<0.001). Patients who received chemotherapy showed significantly longer survival than those who did not (13 vs. 7 months, P=0.032). Patients who underwent gastrectomy plus chemotherapy showed better survival than those who underwent other treatments. In multivariate analysis, gastrectomy was found to be an independent prognostic factor…[Read more]

Influenza A viruses (IAV) and SARS-CoV-2 can spread via liquid droplets and aerosols. Face masks and other personal protective equipment (PPE) can act as barriers that prevent the spread of these viruses. However, IAV and SARS-CoV-2 are stable for hours on various materials, which makes frequent and correct disposal of these PPE important. Metal…[Read more]

To describe the management of arterial partial pressure of carbon dioxide (PaCO

) in severe traumatic brain-injured (TBI) patients, and the optimal target of PaCO

in patients with high intracranial pressure (ICP).

Secondary analysis of CENTER-TBI, a multicentre, prospective, observational, cohort study. The primary aim was to…[Read more]

Non-linear associations were observed between EVI and obese indicators. Participants living in Quartile 3 benefited more than in Quartile 4 compared to the lowest quartile (Quartile 1) of greenness. For peripheral obesity, participants living in Quartile 3 of EVI

had 0.86 kg/m

(β -0.86, 95% CI -1.10, -0.61) lower BMI, and 46% (OR 0.54,…[Read more]

Positive results from recent clinical trials have significantly expanded current therapeutic options for patients with chronic graft-versus-host disease (GVHD). However, new insights into the associations between clinical characteristics of chronic GVHD, pathophysiologic mechanisms of disease, and the clinical and biological effects of novel…[Read more]