Requirements for safety pharmacology testing have been in place since the issue of initial regulatory guidance over 20 years ago. An evaluation of such testing, supporting first clinical entry of 105 small molecule drug candidates over the last decade, showed that a “core battery” of in vitro electrophysiological (hERG), conscious non-rodent…[Read more]

Single-nucleotide polymorphism-based PRS is significantly associated with CFM [P = 7.22 × 10-58, odds ratio = 3.15, 95% confidence interval (CI) 2.74-3.63], and the top fifth percentile has a 6.8-fold CFM risk comparing with the 10th percentile. Father’s smoking increases CFM risk as evidenced by interaction parameter of -0.324 (95% CI -0.578 to…[Read more]

522, P less then 0.01; LDH r=0.600, P less then 0.01). A negative correlation was observed between the lymphocyte count on admission and the severity of illness (r=-0.523, P less then 0.01). There was also a negative correlation between the lymphocyte count on admission and mortality in critical patients (r=-0.499, P less then 0.01). Univariable…[Read more]

e., after these sites are already in place. This study enriches our understanding of how autocrats rule and further opens up an emerging new methodological avenue for research on authoritarian politics.Does the manner in which a civil war is terminated affect women’s political rights developments? In this article, we develop an analytical…[Read more]

We observed that Ca2+, Ba2+, Mn2+ and Mg2+ ions had a positive effect on the activity of ChtCP, and an increase of 30 °C in the melting temperature was observed in the presence of Co2+. These features together with the structure of ChtCP at 1.2 Å highlight the relevance of ChtCP for further biotechnological applications.14-3-3 proteins are a l…[Read more]

It was also observed that prokaryotic diversity and abundance were higher in the more oligotrophic ABt and ABg forest despite the constantly waterlogged condition. In MPS, the methanotroph Methylovirgula ligni was found to be the major species in this forest type that utilize methane (CH4), which could potentially be the contributing factor to the…[Read more]

Cerebrotendinous xanthomatosis (CTX) is a lipid storage disease caused by deficiency of sterol 27-hydroxylase enzyme encoded by CYP27A1 gene. This multicenter, cross-sectional descriptive study aimed to document clinical characteristics of CTX patients of different ages, clinical presentations of early-diagnosed patients, and responses to…[Read more]