009 and p = 0.015, respectively). Most physicians were either “satisfied” (4/5) or “very satisfied” (5/5) (75.0%). On average, physicians felt that physical examinations conducted through telemedicine were “moderately effective” (2.75/5.00 ± 1.3), that they were “fairly confident” (3.86/5.00 ± 0.83) in their diagnoses, and that most sports medicine attendings plan to use telemedicine in the future (87.5%). Conclusion Telehealth emerged as a valuable tool for the delivery of health care to sports medicine patients during the COVID-19 pandemic. Patients and physicians reported high levels of satisfactions with its use, and this study further identifies areas that can improve the patient and physician experience.The Schiff base ligand, 3-(2-(2, 4-dihydroxybenzylidene) hydrazinyl) quinoxalin-2(1H)-one (RHQO) has been synthesized and characterized by spectral and single crystal X-ray analysis. The Mn(II), Ni(II) and Cu(II) complexes of RHQO have been synthesized and characterized by FT-IR, UV-VIS, mass, EPR spectra, CHN, thermo gravimetric analysis, magnetic susceptibility and conductivity measurements. The morphology of the ligand and complexes is studied by Scanning Electron Microscopy. The metal complexes formed were found to be polymeric in nature. The abilities of the ligand and its metal complexes to interact and bind with calf thymus DNA (CT-DNA) has been studied by electronic absorption spectroscopy and their quantitative binding strength was evaluated in terms of their intrinsic binding constant (Kb). The cleavage interaction of the ligand and its metal complexes with super coiled pBR 322 DNA has been investigated by agarose gel electrophoresis. Cytotoxicity of the Cu(II) and Ni(II) complexes was evaluated using various cancer cell lines, Human cervical cancer cell line (Hela), B16 melanoma F10(B16-F10), Human ovarian cancer cell (SKOV3) and Breast cancer cell line (MCF7) by MTT assay. The results indicated that the ligand and its metal complexes bind with CT-DNA by groove binding mode and cleaved the supercoiled pBR 322 DNA in to nicked form. The Ni(II) and Cu(II) complexes exhibited anticancer activity without affecting the normal CHO-K1 cell lines. Communicated by Vsevolod Makeev.Therapeutic hypothermia acts as the standard of care for infants with moderate to severe hypoxic ischemic encephalopathy (HIE). A proportion of neonates who undergo hypothermia due to HIE have shown to develop various degrees of hearing impairment. Analyzing and identifying infants at high risk of developing hearing difficulties is fundamental for early intervention of such auditory complications. The aim was to assess clinical factors in the development of hearing impairment following therapeutic hypothermia in HIE infants. A retrospective analysis was performed on infants hospitalized in our neonatology department in Poznan University of Medical Sciences, Poland. All infants experienced moderate to severe HIE, and were treated with therapeutic hypothermia. Risk factors for hearing impairment were identified in all infants included in the study. Clinical data during hospital stay and follow-up hearing status were analyzed. A total of 87 HIE infants were included in the study. Seventy-six infants (40 male and 36 female) had otoacoustic emission (OAE) examination following birth, of which 14 (18.4%) demonstrated abnormal (positive) results. Infants with abnormal OAE results had significantly lower blood pH (6.86 ± 0.16, p = 0.001) and base excess (BE) (-22.46 ± 2.59, p = 0.006). Of the 49 infants who returned for follow-up assessment, 4 (8.2%) were diagnosed with sensorineural bilateral hearing impairment (1 infant, mild [90 dB]). The biochemical analysis following birth revealed significantly lower umbilical BE levels (-23.90 ± 4.99, p = 0.041) and higher lactate levels (160.67 ± 4.93, p = 0.019) in the infants with eventual sensorineural hearing deficit. see more Infants with moderate or severe HIE are at risk of delayed onset hearing loss. Diligent efforts to monitor auditory status are required, even if early screening results for hearing are insignificant. Exploring biochemical parameters, such as lactate, BE, and blood pH, can prove beneficial in identifying HIE infants at risk of developing a hearing impairment.Mobilization of asbestos fibers from a 60-year-old corrugated asbestos cement roof was studied in material samples collected from a domestic house in Southern-Norway. Samples included pieces of the roof itself, rainfall simulated run off-water and moss growing on the roof surface. Weathered roof debris below the rain water system was investigated for asbestos fibers leached from the roof, and air samples were collected for asbestos concentrations in ambient air. Micrographs obtained by scanning electron microscopy show that weathering exposed asbestos fibers on the deteriorated roof surface. A high number of fibers found in the run off-water as well as in the weathered roof debris sample illustrates that exposed fibers are prone to mobilization. Investigation of weathering-induced magnesium depletion by scanning electron microscopy energy dispersive X-ray spectroscopy of asbestos fibers collected from the moss, roof underside and surface revealed that fibers had MgO weight % comparable to reference material. The major element chemistry of the fibers is therefore unaltered. Our findings demonstrate that care must be taken when working on and handling old corrugated asbestos cement roof as asbestos fibers might be released. In order to limit exposure to mobile fibers, moss covering asbestos cement roof should not be removed.This article reviews one of the most famous cases of lead poisoning in France, the Ponchon affair, which occurred in 1843 during a crucial period for French toxicology. The trial attracted public attention and inflamed controversy among medical and legal experts. The debate involved toxicological methods and their reliability, and gave rise to more general questions about the value of expert evidence, the way it was presented in court, and its relationship to other forms of legal evidence. I begin with a general overview of lead poisoning and toxicological research on lead compounds around 1840. I then discuss different toxicological proofs employed for detecting or preventing lead poisoning and examine as well growing uncertainties about them. A review of several trials related to lead poisoning in workplaces around 1840 introduces the Ponchon affair. Here I present the experts involved in the trial and describe their strategies for presenting and managing proofs and uncertainties. Finally, I summarise the controversy aroused by the trial in medical and legal communities as it relates to the value of jury trials in cases of poisoning, the risks of using too much chemistry in judicial inquiries, and the different proposals for managing uncertainties and disagreements among experts.