05), with Tn lower than Tv and Tt lower than both Tv and Tn. Similarities in circadian rhythm patterns were observed across the day between Tv, Tn and Tt in repeated measures analysis, with a short period of difference between Tv and Tn (from 1400 to 1600 h) and a long period of difference between Tv and Tt (from 1000 to 2100 h) (P less then…[Read more]

Functional magnetic resonance imaging (fMRI) of blood oxygenation level dependent (BOLD) signals during the resting-state is widely used to study functional connectivity (FC) of slowly fluctuating ongoing brain activity (BOLD-FC) in humans with and without brain diseases. While physiological impairments, e.g. aberrant perfusion or vascular…[Read more]

This study demonstrates that SIRT2 is actively transported into the nucleus via a process regulated by its C-terminus and provides a resource of SIRT2 interacting partners.This study aimed to validate a fully automatic method to quantify knee-extensor muscle volume and exercise-induced hypertrophy. By using a magnetic resonance imaging-based…[Read more]

The CRISPR-Cas9 system has been adapted for transcriptional activation (CRISPRa) and several second-generation CRISPRa systems (including VPR, SunTag, and SAM) have been developed to recruit different transcriptional activators to a deactivated Cas9, which is guided to a transcriptional start site via base complementarity with a target guide RNA.…[Read more]